지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.25 No.2
- 발행연도
- 2020.6
- 수록면
- 166 - 172 (7page)
- DOI
- 10.3746/pnf.2020.25.2.166
이용수
초록· 키워드
오류제보하기
Development of anti-inflammatory products remains in high demand due to the incidence of inflammatory diseases, including diabetes, cardiovascular disease, and neurodegenerative diseases. In this study, we examined the potential anti-inflammatory activity of the nutraceutical, Kmeria duperreana (Pierre) Dandy extract (KDE). We evaluated the ability of KDE to inhibit lipopolysaccharide (LPS)-induced inflammatory markers, including nitric oxide (NO), nuclear factor kappa-B, and mitogen-activated protein kinases, in RAW 264.7 cells. KDE suppressed LPS-induced nitrite production and inducible NO synthase (iNOS) expression in RAW 264.7 cells, but has no effect on cyclooxygenase-2 expression. KDE also suppressed LPS-induced phosphorylation of p65, IκB kinase, and p38 in RAW 264.7 cells. Through Western blot assays and immunofluorescence results, we showed that KDE suppresses LPS-induced p65 translocation from cytosol to the nucleus in RAW 264.7 cells. Moreover, KDE suppressed mRNA expression of LPS-induced interleukin (IL)-1κ in RAW 264.7 cells, but had no effect on mRNA expression of IL-6 or tumor necrosis factor-α. These results demonstrate that KDE may be a promising anti-inflammatory nutraceutical. KDE may act by suppressing iNOS expression and subsequent NO production by inhibiting phosphorylation of p65 and p38 and suppressing translocation of p65 from the cytosol to the nucleus.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (31)
참고문헌 신청
Baeuerle PA / 1994 / Function and activation of NF-κB in the immune system / Annu Rev Immunol 12:141~179
Brown JD / 2014 / NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis / Mol Cell 56:219~231
Buchanan MM / 2010 / Toll-like receptor 4 in CNS pathologies / J Neurochem 114:13~27
Chi DS / 2012 / Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1 β-activated human mast cells were inhibited by baicalein via regulation of the NF-κB pathway / Clin Mol Allergy 10(3)
Chiurchiù V / 2011 / Chronic inflammatory disorders and their redox control: from molecular mechanisms to therapeutic opportunities / Antioxid Redox Signal 15:2605~2641
Brown JD / 2014 / NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis / Mol Cell 56:219~231
Buchanan MM / 2010 / Toll-like receptor 4 in CNS pathologies / J Neurochem 114:13~27
Chi DS / 2012 / Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1 β-activated human mast cells were inhibited by baicalein via regulation of the NF-κB pathway / Clin Mol Allergy 10(3)
Chiurchiù V / 2011 / Chronic inflammatory disorders and their redox control: from molecular mechanisms to therapeutic opportunities / Antioxid Redox Signal 15:2605~2641
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Anti-inflammatory effect of medicinal plants extracts in LPS-induced RAW264.7 cells
한국식품영양과학회 학술대회발표집
2021 .10
-
Ginsenoside Rf suppressed LPS-induced inflammatory mediators in RAW264.7 macrophages
한국식품영양과학회 학술대회발표집
2016 .10
-
Chrysophanol Suppressed Pro-inflammatory Cytokines Induced by LPS in Raw 264.7 Cells
한국식품영양과학회 학술대회발표집
2019 .10
-
Anti-inflammatory effect of metabolite A derived from plants in LPS-stimulated Raw264.7 cells
한국식품영양과학회 학술대회발표집
2021 .10
-
An anti-inflammatory effect of Melosira nummuloides extracts in RAW264.7 Cells
한국식품영양과학회 학술대회발표집
2021 .10
-
Silibinin Suppresses LPS-induced or PA-induced Inflammation in RAW264.7 cells
한국식품영양과학회 학술대회발표집
2015 .08
-
Anti-Inflammatory Effect of the Hexane Fraction from Root of Ligustrum ovalifolium H. by Suppressing Inducible Cyclooxygenase (COX-2) and inducible-Nitric Oxide Synthase (iNOS) in Cultured LPS-Induced RAW 264.7 Macrophage Cells
한국약용작물학회 학술대회논문집
2016 .05
-
Antioxidant and Anti-inflammatory Effect of Fermented Rhynchosia nulubilis Extract
한국식품영양과학회 학술대회발표집
2021 .10
-
Raw 264.7 대식세포에서 Chrysophanol의 LPS로 유도된 전염증성 사이토카인 억제 효과
한국식품영양과학회지
2019 .12
-
Anti-inflammatory effects of the aged garlic extracts in LPS-stimulated RAW264.7 cells
한국식품영양과학회 학술대회발표집
2022 .10
-
Fermentation Characteristics and Anti-Inflammatory Effect on LPS-Induced RAW 264.7 Cells of Ginseng Vinegar
한국식품영양과학회 학술대회발표집
2020 .10
-
Anti-Inflammatory Potential of 4,5-Dicaffeoylquinic Acid Derived from Anthriscus sylvestris Leaves Extract in LPS-Stimulated RAW264.7 Cells and in a Rat Model of Carrageenan-Induced Inflammation
한국식품영양과학회 학술대회발표집
2021 .10
-
Responses of infammationsignaling pathway by Pyrrosia lingua extracts on pro-infammatoryresponses in LPS-stimulated Raw 264.7 cell
한국식품영양과학회 학술대회발표집
2021 .10
-
Lipopolysaccharide로 유도된 RAW 264.7 세포에서 유색미 에탄올 추출물의 항염증 작용
한국식품영양과학회지
2018 .09
-
LPS로 자극한 대식세포에서 대두배아 추출물의 항염증 효과
한국식품영양과학회지
2019 .11
-
Inhibitory Effect of Black Radish (Raphanus sativus L. var. niger) Extracts on Lipopolysaccharide-Induced Inflammatory Response in the Mouse Monocyte/Macrophage-Like Cell Line RAW 264.7
Preventive Nutrition and Food Science
2020 .12
-
Anti-inflammatory effect of the cell extracts from Saccharomyces boulardii in LPS-induces Raw 264.7 macrophages
한국식품영양과학회 학술대회발표집
2023 .10
-
The Natural Product PL Ethanol Extract Protects Inflammatory Mediated Responses in LPS-stimulated RAW 264.7 Macrophage via Regulation of NF-kappaB Signaling Pathway
한국식품영양과학회 학술대회발표집
2021 .10
-
LPS로 유도된 RAW264.7 세포주 염증모델에서 소리쟁이의 법제처리에 따른 항염증 효과
한국식품영양학회지
2019 .01
-
Anti-inflammatory activities of Scutellaria baicalensis root extract on LPS-induced in RAW 264.7 cells
한국식품영양과학회 학술대회발표집
2020 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2020-594-000846901