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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.2
- 수록면
- 21 - 28 (8page)
- DOI
- 10.7783/KJMCS.2020.28.1.21
이용수
초록· 키워드
오류제보하기
Background: Owing to its high efficiency in lipid and protein production, peanut (Arachis hypogaea L.) is considered one of most important crops world-wide. The kernels of peanuts are undoubtedly the most important product this plant, whereas the skin is almost completely neglected in nutraceutical terms. However, peanut skin contains potentially health-promoting phenolics and dietary fiber, and there is considerable potential for commercial exploitation. In this study, we evaluated the α-glucosidase inhibitory activity of an extract of peanut skin (PS).
Methods and Results: The α-glucosidase inhibitory effects of 80% ethanol extracts of peanut (A. hypogaea L. ‘Sinpalkwang’) skin were evaluated and found to have a half-maximal inhibitory concentration (IC<SUB>50</SUB>) value of 1.2 ㎍/㎖. Progress curves for enzyme reactions were recorded spectrophotometrically, and the inhibition kinetics revealed time-dependent inhibition with enzyme isomerization. Furthermore, using ultra-high performance liquid chromatography combined with quadrupole-orbitrap mass spectrometry, we identified 26 compounds in the peanut skin extract, namely, catechin, epicatechin, and 24 proanthocyanidins.
Conclusions: The results suggest that peanut skin can be utilized as an effective source of α-glucosidase inhibition in functional foods and nutraceuticals.
Methods and Results: The α-glucosidase inhibitory effects of 80% ethanol extracts of peanut (A. hypogaea L. ‘Sinpalkwang’) skin were evaluated and found to have a half-maximal inhibitory concentration (IC<SUB>50</SUB>) value of 1.2 ㎍/㎖. Progress curves for enzyme reactions were recorded spectrophotometrically, and the inhibition kinetics revealed time-dependent inhibition with enzyme isomerization. Furthermore, using ultra-high performance liquid chromatography combined with quadrupole-orbitrap mass spectrometry, we identified 26 compounds in the peanut skin extract, namely, catechin, epicatechin, and 24 proanthocyanidins.
Conclusions: The results suggest that peanut skin can be utilized as an effective source of α-glucosidase inhibition in functional foods and nutraceuticals.
목차
ABSTRACT
서언
재료 및 방법
결과 및 고찰
REFERENCES
참고문헌 (30)
참고문헌 신청
Case A / 2007 / Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor / Biochemistry 46:1106~1115
Caspary WF / 1978 / Sucrose malabsorption in man after ingestion of α-glucosidehydrolase inhibitor / The Lancet 311:1231~1233
Chen L / 2018 / Procyanidin from peanut skin induces antiproliferative effect in human prostate carcinoma cell DU145 / ChemicoBiological Interactions 288:12~23
Copeland RA / 2000 / Enzyme: A practical introduction to structure, mechanism, and data analysis / Wiley-VCH :266~304
Dong XQ / 2013 / Preparation of A-type proanthocyanidin dimers from peanut skins and persimmon pulp and comparison of the antioxidant activity of A-type and B-type dimers / Fitoterapia 91:128~139
Caspary WF / 1978 / Sucrose malabsorption in man after ingestion of α-glucosidehydrolase inhibitor / The Lancet 311:1231~1233
Chen L / 2018 / Procyanidin from peanut skin induces antiproliferative effect in human prostate carcinoma cell DU145 / ChemicoBiological Interactions 288:12~23
Copeland RA / 2000 / Enzyme: A practical introduction to structure, mechanism, and data analysis / Wiley-VCH :266~304
Dong XQ / 2013 / Preparation of A-type proanthocyanidin dimers from peanut skins and persimmon pulp and comparison of the antioxidant activity of A-type and B-type dimers / Fitoterapia 91:128~139
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