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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.10
- 수록면
- 537 - 541 (5page)
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초록· 키워드
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Toxoplasma gondii infection induces parasite infiltration and apoptosis in the spleen. However, dose-dependent parasite infiltration, apoptosis, body weight alternations and survival in mice remain largely unknown. In this study, mice were intraperitoneally infected with 10, 30 or 100 tachyzoites of T. gondii, respectively. Parasite infiltration and apoptosis in the spleen were analyzed on days 3, 7, and 9 post-infection by immunohistochemistry and flow cytometry. Significantly higher levels of T. gondii infiltration and apoptosis in the spleen were found in 30 and 100 tachyzoites infected mice compared to 10 tachyzoites infected mice on days 7 and 9 post-infection. Although 30 and 100 tachyzoites infected mice showed significant body weight loss compared to 10 tachyzoites infected mice, all of the 100, 30, and 10 tachyzoites in-fected mice died by days 12, 15, and 17, each respectively. Interestingly, T. gondii infiltration in 10 tachyzoites infected mice were limited to capsule area of the spleen on day 9 post-infection. Several areas of parasite infiltrations were found in the 30 tachyzoites infected mice, where noticeable levels of splenic capsule de-adhesion occurred. These results indicated that parasite infiltration and apoptosis in the spleen, as well as body weight loss (survival) are closely correlated with infection dosage. The level of T. gondii infiltration and apoptosis in the spleen and splenic de-adhesion were dependent on the parasite dose.
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참고문헌 (21)
참고문헌 신청
Montoya JG / 2004 / Toxoplasmosis / Lancet 363:1965~1976
Tenter AM / 2000 / Toxoplasma gondii : from animals to humans / Int J Parasitol 30:1217~1258
Kim K / 2004 / Toxoplasma gondii : the model apicomplexan / Int J Parasitol 34:423~432
Moncada PA / 2012 / Toxoplasmosis in the fetus and newborn : an update on prevalence, diagnosis and treatment / Expert Rev Anti Infect Ther 10:815~828
Wang S / 2015 / Protective immunity against acute toxoplasmosis in BALB/c mice induced by a DNA vaccine encoding Toxoplasma gondii 10 kDa excretory–secretory antigen(TgESA10) / Vet Parasitol 214:40~48
Tenter AM / 2000 / Toxoplasma gondii : from animals to humans / Int J Parasitol 30:1217~1258
Kim K / 2004 / Toxoplasma gondii : the model apicomplexan / Int J Parasitol 34:423~432
Moncada PA / 2012 / Toxoplasmosis in the fetus and newborn : an update on prevalence, diagnosis and treatment / Expert Rev Anti Infect Ther 10:815~828
Wang S / 2015 / Protective immunity against acute toxoplasmosis in BALB/c mice induced by a DNA vaccine encoding Toxoplasma gondii 10 kDa excretory–secretory antigen(TgESA10) / Vet Parasitol 214:40~48
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UCI(KEPA) : I410-ECN-0101-2020-513-000262539