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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.10
- 수록면
- 543 - 547 (5page)
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초록· 키워드
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Toxoplasma gondii can infect humans worldwide, causing serious diseases in pregnant women and immunocompromised individuals. T. gondii rhoptry protein 13 (ROP13) is known as one of the key proteins involved in host cell invasion. In this study, we generated virus-like particles (VLPs) vaccine expressing T. gondii rhoptry ROP13 and investigated VLPs vaccine efficacy in mice. Mice immunized with ROP13 VLPs vaccine elicited significantly higher levels of T. gondii-specific IgG, IgG1, IgG2a, and IgA antibody responses following boost immunization and challenge infection, whereas antibody inductions were insignificant upon prime immunization. Differing immunization routes resulted in differing antibody induction, as intranasal immunization (IN) induced greater antibody responses than intramuscular immuniza-tion (IM) after boost and challenge infection. IN immunization induced significantly higher levels of IgG and IgA antibody responses from feces, antibody-secreting cells (ASCs), CD4<SUP>+</SUP> T, CD8<SUP>+</SUP> T cells and germinal center B cell responses in the spleen compared to IM immunization. Compared to IM immunization, IN immunization resulted in significantly reduced cyst counts in the brain as well as lesser body weight loss, which contributed to better protection. All of the mice immunized through either route survived, whereas all naïve control mice perished. These results indicate that the ROP13 VLPs vaccine could be a potential vaccine candidate against T. gondii infection.
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참고문헌 (12)
참고문헌 신청
Dubey J / 2012 / A review of toxoplasmosis in humans and animals in Ethiopia / Epidemiol Infect 140:1935~1938
Dubey JP / 2010 / Toxoplasmosis of Animals and Humans / CRC press
Wang PY / 2012 / Protective efficacy of a Toxoplasma gondii rhoptry protein 13 plasmid DNA vaccine in mice. Clin / Vaccine Immunol 19:1916~1920
Fatemeh Ghaffarifar / 2019 / Rhoptry antigens as Toxoplasma gondii vaccine target / Clinical and Experimental Vaccine Research 8(1):4~26
Lee SH / 2018 / Virus-like particle vaccines expressing Toxoplasma gondii rhoptry protein 18 and microneme protein 8 provide enhanced protection / Vaccine 36:5692~5700
Dubey JP / 2010 / Toxoplasmosis of Animals and Humans / CRC press
Wang PY / 2012 / Protective efficacy of a Toxoplasma gondii rhoptry protein 13 plasmid DNA vaccine in mice. Clin / Vaccine Immunol 19:1916~1920
Fatemeh Ghaffarifar / 2019 / Rhoptry antigens as Toxoplasma gondii vaccine target / Clinical and Experimental Vaccine Research 8(1):4~26
Lee SH / 2018 / Virus-like particle vaccines expressing Toxoplasma gondii rhoptry protein 18 and microneme protein 8 provide enhanced protection / Vaccine 36:5692~5700
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UCI(KEPA) : I410-ECN-0101-2020-513-000262524