Immune Responses Induced by HSP60 DNA Vaccine against Toxoplasma gondii Infection in Kunming Mice

Zhong-Yuan Li; Jing Lu; Nian-Zhang Zhang; Jia Chen; Xing-Quan Zhu

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자료유형: 학술저널

저자정보: Zhong-Yuan Li (Anhui Agricultural University) Jing Lu (Guangdong Wens Dahuanong Biotechnology) Nian-Zhang Zhang (Chinese Academy of Agricultural Sciences) Jia Chen (Ningbo University School of Medicine) Xing-Quan Zhu (Chinese Academy of Agricultural Sciences)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.56 No.3

발행연도: 2018.6

수록면: 237 - 245 (9page)

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Toxoplasma gondii can infect all the vertebrates including human, and leads to serious toxoplasmosis and considerable veterinary problems. T. gondii heat shock protein 60 (HSP60) is associated with the activation of antigen presenting cells by inducing initial immune responses and releasing inflammatory cytokines. It might be a potential DNA vaccine candidate for this parasite. A pVAX-HSP60 DNA vaccine was constructed and immune responses was evaluated in Kunming mice in this study. Our data indicated that the innate and adaptive immune responses was elicited by successive immunizations with pVAX-HSP60 DNA, showing apparent increases of CD3e+CD4+ and CD3e+CD8a+ T cells in spleen tissues of the HSP60 DNA-immunized mice (24.70±1.23% and 10.90±0.89%, P<0.05) and higher levels of specific antibodies in sera. Furthermore, the survival period of the immunized mice (10.53±4.78 day) were significantly prolonged during the acute T. gondii infection. Decrease of brain cysts was significant in the experimental group during the chronic infection (P<0.01). Taken together, TgHSP60 DNA can be as a vaccine candidate to prevent the acute and chronic T. gondii infections.

#Toxoplasma gondii #HSP60 DNA #Kunming mouse #immune response

참고문헌 (30)

참고문헌 신청

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