Toxoplasma gondii Induces Apoptosis via Endoplasmic Reticulum Stress-Derived Mitochondrial Pathway in Human Small Intestinal Epithelial Cell-Line

Hao Wang; Chunchao Li; Wei Ye; Zhaobin Pan; Jinhui Sun; Mingzhu Deng; Weiqiang Zhan; Jiaqi Chu

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자료유형: 학술저널

저자정보: Hao Wang (Affiliated Hospital of Guangdong Medical University) Chunchao Li (Affiliated Hospital of Guangdong Medical University) Wei Ye (Affiliated Hospital of Guangdong Medical University) Zhaobin Pan (Affiliated Hospital of Guangdong Medical University) Jinhui Sun (Affiliated Hospital of Guangdong Medical University) Mingzhu Deng (Affiliated Hospital of Guangdong Medical University) Weiqiang Zhan (Affiliated Hospital of Guangdong Medical University) Jiaqi Chu (Affiliated Hospital of Guangdong Medical University)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.59 No.6

발행연도: 2021.12

수록면: 573 - 583 (11page)

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Toxoplasma gondii, an intracellular protozoan parasite that infects one-third of the world’s population, has been reported to hijack host cell apoptotic machinery and promote either an anti- or proapoptotic program depending on the parasite virulence and load and the host cell type. However, little is known about the regulation of human FHs 74 small intestinal epithelial cell viability in response to T. gondii infection. Here we show that T. gondii RH strain tachyzoite infection or ESP treatment of FHs 74 Int cells induced apoptosis, mitochondrial dysfunction and ER stress in host cells. Pretreatment with 4-PBA inhibited the expression or activation of key molecules involved in ER stress. In addition, both T. gondii and ESP challenge-induced mitochondrial dysfunction and cell death were dramatically suppressed in 4-PBA pretreated cells. Our study indicates that T. gondii infection induced ER stress in FHs 74 Int cells, which induced mitochondrial dysfunction followed by apoptosis. This may constitute a potential molecular mechanism responsible for the foodborne parasitic disease caused by T. gondii.

#Toxoplasma gondii #ER stress #mitochondrial apoptosis #FHs 74 Int cell

참고문헌 (28)

참고문헌 신청

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Desmonts, G / 197 / Congenital toxoplasmosis. A prospective study of 378 pregnancies / N Engl J Med 290:1110~1116

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