지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 565 - 572 (8page)
이용수
초록· 키워드
오류제보하기
Toxoplasma gondii ME49 infections are typically diagnosed by serological tests. However, serological diagnosis of RH strain-induced toxoplasmosis remains unknown. In order to develop seradiagnosis of above 2 kinds of infections, we generated recombinant virus-like particles (VLPs) displaying the T. gondii rhoptry protein 4 (ROP4) and evaluated their potential in T. gondii ME49 or RH strain infection diagnostics. Mice were orally infected with either the tachyzoites of T. gondii (RH) or cysts of T. gondii (ME49) at various dosages, and sera were collected at regular intervals. ELISA-based serological tests were performed to assess IgG, IgM, and IgA antibody responses against ROP4 VLP antigen and tissue lysate antigen (TLA). Compared to TLA, IgG, IgM, and IgA levels to ROP4 VLP antigen were significantly higher in the sera of T. gondii RH-infected mice 1 and 2 week post-infection (PI). T. gondii-specific IgG antibody was detected at 1, 2, 4, and 8 week PI in the T. gondii ME49-infected mice with infection dose-dependent manner. These results indicated that the ROP4 VLP antigen was highly sensitive antigens detecting T. gondii RH and ME49 antibodies at an early stage.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (34)
참고문헌 신청
Halonen SK / 2013 / Handbook of Clinical Neurology / Elsevier :125~145
Yarovinsky F / 2008 / Toll-like receptors and their role in host resistance to Toxoplasma gondii / Immunol Lett 119:17~21
Howe DK / 1995 / Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease / J Infect Dis 172:1561~1566
Lee SH / 2019 / Protective immunity induced by incorporating multiple antigenic proteins of Toxoplasma gondii into influenza virus-like particles / Front Immunol 9:3073
Hosseininejad M / 2012 / Evaluation of an indirect ELISA using a tachyzoite surface antigen SAG1 for diagnosis of Toxoplasma gondii infection in cats / Exp Parasitol 132:556~560
Yarovinsky F / 2008 / Toll-like receptors and their role in host resistance to Toxoplasma gondii / Immunol Lett 119:17~21
Howe DK / 1995 / Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease / J Infect Dis 172:1561~1566
Lee SH / 2019 / Protective immunity induced by incorporating multiple antigenic proteins of Toxoplasma gondii into influenza virus-like particles / Front Immunol 9:3073
Hosseininejad M / 2012 / Evaluation of an indirect ELISA using a tachyzoite surface antigen SAG1 for diagnosis of Toxoplasma gondii infection in cats / Exp Parasitol 132:556~560
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UCI(KEPA) : I410-ECN-0101-2022-513-001354076