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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 208 - 215 (8page)
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In this paper, we investigate to determine quality characteristics, fatty acid composition and cytotoxic effect of extracts and fractions from whole Lycopus lucidus Turcz. roots. Additionally, we evaluated cytotoxic activity against the growth of human fibrosarcoma cells (HT-1080) and human gastric adenocarcinoma (AGS), human colon cancer cell (HT-29) lines using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Acetone+methylene chloride (A+M) and methanol (MeOH) extracts from L. lucidus Turcz. were obtained through solvent extraction. Then we further fractionated both extracts with n-hexane, 85% aq. MeOH, n-butanol (n-BuOH) and water. In fatty acid composition, L. lucidus Turcz. contained 33.2% of 18:1n-9 and 1.81% of 18:3n-3, respectively. The incorporation of treatment with A+M and MeOH extracts and n-hexane, 85% aq. MeOH, n-butanol (n-BuOH) and water fractions dose-dependently increased cytotoxicity against the growth of HT-1080 and AGS, HT-29 cancer cells (p<0.05). The A+M extract had a higher inhibitory effect on the growth of all cancer cells in comparison to MeOH extract. Among the fractions, the 85% aq. MeOH and n-hexane fractions showed a higher inhibitory effect after proliferating the three cancer cells. These results suggest that the 85% aq. MeOH and n-hexane fractions have a potential to inhibit the growth of human cancer cell lines.
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참고문헌 (32)
참고문헌 신청
AOAC / 1996 / The Association Official Methods of Analysis / Association of Official Analytical Chemists :210~219
Carrillo C / 2012 / Antitumor effect of oleic acid : Mechanisms of action : A review / Nutr Hosp 27:1860~1865
최일숙 / 2012 / 한방생약재를 이용한 약선차의 항산화 및 항암효과 / 한국식품영양학회지 25(3):447~453
Dai J / 2013 / Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro / Lipids Health Dis 12:71
Denizot F / 1986 / Rapid colorimetric assay for cell growth and survival. modifications to the tetrazolium dye procedure giving improved sensitivity and reliability / J Immunol Methods 89:271~277
Carrillo C / 2012 / Antitumor effect of oleic acid : Mechanisms of action : A review / Nutr Hosp 27:1860~1865
최일숙 / 2012 / 한방생약재를 이용한 약선차의 항산화 및 항암효과 / 한국식품영양학회지 25(3):447~453
Dai J / 2013 / Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro / Lipids Health Dis 12:71
Denizot F / 1986 / Rapid colorimetric assay for cell growth and survival. modifications to the tetrazolium dye procedure giving improved sensitivity and reliability / J Immunol Methods 89:271~277
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