지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.21 No.4
- 발행연도
- 2016.12
- 수록면
- 384 - 388 (5page)
이용수
초록· 키워드
오류제보하기
Reactive oxygen species are tumorigenic by their ability to increase cell proliferation, survival, and cellular migration. The purpose of the present study was to compare the antioxidant activity and cytotoxic effects of 3 berry extracts (strawberry, Korean raspberry, and mulberry) in A2780 human ovarian carcinoma cells. Except for raspberry, the ethyl acetate or methylene chloride fractions of berries containing phenolic compounds exerted dose dependent free radical scavenging activities. In the raspberry fractions, the hexane fraction also exhibited potent antioxidant activity. The cytotoxic effects of berries extracts in A2780 human ovarian carcinoma cells were measured using the 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide assay. Surprisingly, co-treatment with n-butanol (BuOH) fractions of berries showed stronger cytotoxic effects compared to the other fractions. These findings suggest that potent anticancer molecules are found in the BuOH fractions of berries that have stronger cytotoxic activity than antioxidants.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
[학술지(정기간행물)] - Reuter S / 2010 / Oxidative stress, inflammation, and cancer : how are they linked? / Free Radic Biol Med 49 : 1603 ~ 1616
[학술지(정기간행물)] - Guyton KZ / 1993 / Oxidative mechanisms in carcinogenesis / Br Med Bull 49 : 523 ~ 544
[학술지(정기간행물)] - Schulte-Hermann R / 1990 / DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion / Cancer Res 50 : 5127 ~ 5135
[학술지(정기간행물)] - Frenkel K / 1992 / Carcinogen-mediated oxidant formation and oxidative DNA damage / Pharmacol Ther 53 : 127 ~ 166
[학술지(정기간행물)] - Han X / 2013 / A2780human ovarian cancer cells with acquired paclitaxel resistance display cancer stem cell properties / Oncol Lett 6 : 1295 ~ 1298
[학술지(정기간행물)] - Guyton KZ / 1993 / Oxidative mechanisms in carcinogenesis / Br Med Bull 49 : 523 ~ 544
[학술지(정기간행물)] - Schulte-Hermann R / 1990 / DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion / Cancer Res 50 : 5127 ~ 5135
[학술지(정기간행물)] - Frenkel K / 1992 / Carcinogen-mediated oxidant formation and oxidative DNA damage / Pharmacol Ther 53 : 127 ~ 166
[학술지(정기간행물)] - Han X / 2013 / A2780human ovarian cancer cells with acquired paclitaxel resistance display cancer stem cell properties / Oncol Lett 6 : 1295 ~ 1298
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UCI(KEPA) : I410-ECN-0101-2017-594-002040611