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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 906 - 914 (9page)
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초록· 키워드
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Purpose Papillary thyroid carcinomas (PTCs) frequently involve genetic alterations. The objective of this study was to investigate genetic alterations and further explore the relationships between these genetic alterations and clinicopathological characteristics in a high-recurrence risk (node positive, N1) PTC group.
Materials and Methods Tumor tissue blocks were obtained from 240 surgically resected patients with histologically confirmed stage III/IV (pT3/4 or N1) PTCs. We screened gene fusions using NanoString’s nCounter technology and mutational analysis was performed by direct DNA sequencing. Data describing the clinicopathological characteristics and clinical courses were retrospectively collected.
Results Of the 240 PTC patients, 207 (86.3%) had at least one genetic alteration, including BRAF mutation in 190 patients (79.2%), PIK3CAmutation in 25 patients (10.4%), NTRK1/3 fusion in six patients (2.5%), and RET fusion in 24 patients (10.0%). Concomitant presence of more than two genetic alterations was seen in 36 patients (15%). PTCs harboring BRAF mutation were associated with RET wild-type expression (p=0.001). RET fusion genes have been found to occur with significantly higher frequency in N1b stage patients (p=0.003) or groups of patients aged 45 years or older (p=0.031); however, no significant correlation was found between other genetic alterations. There was no trend toward favorable recurrence- free survival or overall survival among patients lacking genetic alterations.
Conclusion In the selected high-recurrence risk PTC group, most patients had more than one genetic alteration. However, these known alterations could not entirely account for clinicopathological features of high-recurrence risk PTC.
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참고문헌 (25)
참고문헌 신청
Adeniran AJ / 2006 / Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas
Benvenga S / 2014 / Molecular pathways associated with aggressiveness of papillary thyroid cancer / Curr Genomics 15 : 162 ~ 170
Cancer Genome Atlas Research Network / 2014 / Integrated genomic characterization of papillary thyroid carcinoma / Cell 159 : 676 ~ 690
Cheng SP / 2014 / Significance of allelic percentage of BRAF c.1799T > A (V600E) mutation in papillary thyroid carcinoma / Ann Surg Oncol 21 (Suppl 4) : S619 ~ S626
Chitikova Z / 2015 / Identification of new biomarkers for human papillary thyroid carcinoma employing NanoString analysis / Oncotarget 6 : 10978 ~ 10993
Benvenga S / 2014 / Molecular pathways associated with aggressiveness of papillary thyroid cancer / Curr Genomics 15 : 162 ~ 170
Cancer Genome Atlas Research Network / 2014 / Integrated genomic characterization of papillary thyroid carcinoma / Cell 159 : 676 ~ 690
Cheng SP / 2014 / Significance of allelic percentage of BRAF c.1799T > A (V600E) mutation in papillary thyroid carcinoma / Ann Surg Oncol 21 (Suppl 4) : S619 ~ S626
Chitikova Z / 2015 / Identification of new biomarkers for human papillary thyroid carcinoma employing NanoString analysis / Oncotarget 6 : 10978 ~ 10993
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