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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 55 - 64 (10page)
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초록· 키워드
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Background: Arachidonic acid (AA) is an omega-6 polyunsaturated fatty acid present in all mammalian cell membranes, and involved in the regulation of many cellular processes, including cell survival, angiogenesis, and mitogenesis.
The dermal papilla, composed of specialized fibroblasts located in the bulb of the hair follicle, contributes to the control of hair growth and the hair cycle. Objective: This study investigated the effect of AA on hair growth by using in vivo and in vitro models. Methods: The effect of AA on human dermal papilla cells (hDPCs) and hair shaft elongation was evaluated by MTT assay and hair follicle organ culture, respectively. The expression of various growth and survival factors in hDPCs were investigated by western blot or immunohistochemistry. The ability of AA to induce and prolong anagen phase in C57BL/6 mice was analyzed. Results: AA was found to enhance the viability of hDPCs and promote the expression of several factors responsible for hair growth, including fibroblast growth factor-7 (FGF-7) and FGF-10.
Western blotting identified the role of AA in the phosphorylation of various transcription factors (ERK, CREB, and AKT) and increased expression of Bcl-2 in hDPCs. In addition, AA significantly promoted hair shaft elongation, with increased proliferation of matrix keratinocytes, during ex vivo hair follicle culture. It was also found to promote hair growth by induction and prolongation of anagen phase in telogen-stage C57BL/6 mice. Conclusion: This study concludes that AA plays a role in promoting hair growth by increasing the expression of growth factors in hDPCs and enhancing follicle proliferation and survival.
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참고문헌 (44)
참고문헌 신청
Paine E. / 2000 / Arachidonic acid activates mitogen-activated protein(MAP)kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway / J Biol Chem 275:11284~11290
Clària J / 2006 / Regulation of cell proliferation and apoptosis by bioactive lipid mediators / Recent Pat Anticancer Drug Discov 1:369~382
Cabral M. / 2013 / Role of arachidonic acid metabolites on the control of non-differentiated intestinal epithelial cell growth / Int J Biochem Cell Biol 45:1620~1628
Bogatcheva NV. / 2005 / Arachidonic acid cascade in endothelial pathobiology / Microvasc Res 69:107~127
Tragni E. / 1988 / Arachidonic acid metabolism in HEL/30 murine epidermal cell line / Arch Dermatol Res 280:437~442
Clària J / 2006 / Regulation of cell proliferation and apoptosis by bioactive lipid mediators / Recent Pat Anticancer Drug Discov 1:369~382
Cabral M. / 2013 / Role of arachidonic acid metabolites on the control of non-differentiated intestinal epithelial cell growth / Int J Biochem Cell Biol 45:1620~1628
Bogatcheva NV. / 2005 / Arachidonic acid cascade in endothelial pathobiology / Microvasc Res 69:107~127
Tragni E. / 1988 / Arachidonic acid metabolism in HEL/30 murine epidermal cell line / Arch Dermatol Res 280:437~442
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