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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 395 - 401 (7page)
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초록· 키워드
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Background: Chrysanthemum zawadskii (CZ) belongs to the genus Chrysanthemum, also known as ‘Gu-Jeol-Cho’ in Korea. CZ has been used as herbal remedy to manage cough, hypertensive disorders, pharyngitis, bronchitis, gastroenteritis, pneumonia, bladder diseases and common cold. However, its effect on hair growth has not been documented. Objective: The aim of present study was to elucidate the beneficial effects of CZ on hair growth. Methods: Proliferation of follicular dermal papilla (DP) cells from human scalp skin was evaluated by MTT assay. The expression of various molecules in DP cells was checked by western blot assay. Effect of CZ extract on the hair growth was evaluated by hair organ culture and C57BL/6 mice model. Results: Cultivation of DP cells with CZ extract increased cellular proliferation, increased expression of phosphorylated protein kinase B (p-Akt), p-ERK, B-cell lymphoma 2, and decreased expression of Bax. Treatment of human hair follicles with CZ extract significantly enhanced hair growth. Additionally, CZ markedly shortened telogen period, increased anagen transformation and stimulated hair growth in the animal study. Conclusion: These results suggest that CZ extract has an effect of promoting hair growth and may therefore be a useful a therapeutic remedy for preventing hair loss.
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참고문헌 (10)
참고문헌 신청
Pi LQ / 2013 / Effects of calcitonin gene-related peptide on the immune privilege of human hair follicles / Neuropeptides 47:51~57
Messenger AG / 1984 / The culture of dermal papilla cells from human hair follicles / Br J Dermatol 110:685~689
Müller-Röver S / 2001 / A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages / J Invest Dermatol 117:3~15
Han JH / 2004 / Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle / J Dermatol Sci 34:91~98
Schneider MR / 2009 / The hair follicle as a dynamic miniorgan / Curr Biol 19:R132~R142
Messenger AG / 1984 / The culture of dermal papilla cells from human hair follicles / Br J Dermatol 110:685~689
Müller-Röver S / 2001 / A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages / J Invest Dermatol 117:3~15
Han JH / 2004 / Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle / J Dermatol Sci 34:91~98
Schneider MR / 2009 / The hair follicle as a dynamic miniorgan / Curr Biol 19:R132~R142
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