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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제5호
- 발행연도
- 2018.9
- 수록면
- 555 - 566 (12page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.5.555
이용수
이 논문의 연구 히스토리 (2)
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초록· 키워드
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Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) are used in tissue repair and regeneration; however, the mechanisms involved are not well understood. We investigated the hair growth-promoting effects of hUCB-MSCs treatment to determine whether hUCB-MSCs enhance the promotion of hair growth.
Furthermore, we attempted to identify the factors responsible for hair growth. The effects of hUCB-MSCs on hair growth were investigated in vivo, and hUCB-MSCs advanced anagen onset and hair follicle neogeneration. We found that hUCB-MSCs co-culture increased the viability and up-regulated hair induction-related proteins of human dermal papilla cells (hDPCs) in vitro. A growth factor antibody array revealed that secretory factors from hUCB-MSCs are related to hair growth. Insulin-like growth factor binding protein-1 (IGFBP-1) and vascular endothelial growth factor (VEGF) were increased in co-culture medium. Finally, we found that IGFBP-1, through the colocalization of an IGF-1 and IGFBP-1, had positive effects on cell viability; VEGF secretion; expression of alkaline phosphatase (ALP), CD133, and β-catenin; and formation of hDPCs 3D spheroids. Taken together, these data suggest that hUCB-MSCs promote hair growth via a paracrine mechanism.
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참고문헌 (62)
참고문헌 신청
Ferriman D / 1961 / Clinical assessment of body hair growth in women / J Clin Endocrinol Metab 21:1440~1447
Harada T / 1998 / Apoptosis of hair follicle cells in the second-degree burn wound unders hypernatremic conditions / Burns 24:464~469
Leyden J / 1999 / Finasteride in the treatment of men with frontal male pattern hair loss / J Am Acad Dermatol 40:930~937
Sinclair R / 1998 / Male pattern androgenetic alopecia / BMJ 317:865~869
Kligman AM / 1961 / Pathologic dynamics of human hair loss. I. Telogen effuvium / Arch Dermatol 83:175~198
Harada T / 1998 / Apoptosis of hair follicle cells in the second-degree burn wound unders hypernatremic conditions / Burns 24:464~469
Leyden J / 1999 / Finasteride in the treatment of men with frontal male pattern hair loss / J Am Acad Dermatol 40:930~937
Sinclair R / 1998 / Male pattern androgenetic alopecia / BMJ 317:865~869
Kligman AM / 1961 / Pathologic dynamics of human hair loss. I. Telogen effuvium / Arch Dermatol 83:175~198
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