지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 311 - 316 (6page)
이용수
초록· 키워드
오류제보하기
We reviewed our leukemia database to reclassify 610 patients previously diagnosed as having acute myeloid leukemia (AML) according to the updated 2016 WHO classification. Nine patients were categorized as having myelodysplastic syndrome and myeloid neoplasms with germline predisposition. AML with recurrent genetic abnormalities accounted for 57.4% (345/601) of the patients under the 2016 WHO classification. AML with mutated NPM1 was the most common form (16.5%), with the majority associated with monocytic differentiation (63.6%). AML with double CEBPA mutations accounted for 8.3% of these cases, and the majority were previously diagnosed as AML with/without maturation (78.0%). These newly classified mutations were mutually exclusive without overlapping with other forms of AML with recurrent genetic abnormalities. AML with mutated NPM1 and AML with myelodysplasia-related changes comprised the oldest patients, whereas AML with RUNX1-RUNX1T1 included the youngest patients. The leukocyte count was highest in AML with mutated NPM1, and the percentage of peripheral blood blasts was the highest in AML with double CEBPA mutations. Our results indicate that implementation of the 2016 WHO classification of AML would not pose major difficulties in clinical practice. Hematopathologists should review and prepare genetic tests for the new classification, according to their clinical laboratory conditions.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Vardiman JW / 2009 / The 2008 revision of the World Health Organization(WHO)classification of myeloid neoplasms and acute leukemia : rationale and important changes / Blood 114:937~951
Arber DA / 2016 / The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia / Blood 127:2391~2405
McGowan-Jordan J / 2016 / ISCN 2016: an international system for human cytogenomic nomenclature / Karger :7~99
Döhner K / 2005 / Mutant nucleophosmin(NPM1)predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics : interaction with other gene mutations / Blood 106:3740~3746
Falini B / 2009 / Acute myeloid leukemia with mutated NPM1 : diagnosis, prognosis and therapeutic perspectives / Curr Opin Oncol 21:573~581
Arber DA / 2016 / The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia / Blood 127:2391~2405
McGowan-Jordan J / 2016 / ISCN 2016: an international system for human cytogenomic nomenclature / Karger :7~99
Döhner K / 2005 / Mutant nucleophosmin(NPM1)predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics : interaction with other gene mutations / Blood 106:3740~3746
Falini B / 2009 / Acute myeloid leukemia with mutated NPM1 : diagnosis, prognosis and therapeutic perspectives / Curr Opin Oncol 21:573~581
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
한국 고등학생의 음주 미디어 리터러시 교육 요구도 및 관련 요인
보건교육건강증진학회지
2023 .03
-
Myelodysplasia-Related Features of Acute Myeloid Leukemia Evolving From Philadelphia-Negative Myeloproliferative Neoplasms
Annals of Laboratory Medicine
2016 .01
-
Minor BCR-ABL1-Positive Acute Myeloid Leukemia Associated With the NPM1 Mutation and FLT3 Internal Tandem Duplication
Annals of Laboratory Medicine
2016 .01
-
소아 급성골수성백혈병의 진단 및 치료
Clinical Pediatric Hematology-Oncology
2015 .01
-
성인 급성골수성백혈병 치료 전략의 새로운 변화
대한의사협회지
2023 .04
-
FLT3-ITD Mutations in Acute Myeloid Leukemia Patients in Northeast Thailand
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
A Novel KIT INDEL Mutation in Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1
Annals of Laboratory Medicine
2016 .01
-
Characterization of CEBPA Mutations and Polymorphisms and their Prognostic Relevance in De Novo Acute Myeloid Leukemia Patients
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Overexpression of Prohibitin 2 Protein is Associated with Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia
Annals of Laboratory Medicine
2022 .09
-
급성골수성백혈병과 골수이형성증후군 환자를 대상으로 한 NGS 골수성 패널 검사: 단일 상급종합병원에서의 경험
Laboratory Medicine Online
2021 .01
-
Diagnosis and surgical treatment of a rare hepatic angiomyolipoma with internal hemorrhage
Annals of Hepato-Biliary-Pancreatic Surgery
2021 .11
-
FLT3 mutations in acute myeloid leukemia: a review focusing on clinically applicable drugs
Blood Research
2022 .04
-
Acute Myeloid Leukemia Identified Incidentally in Patient with Infected Extraction Socket through Preoperative Screening Blood Test: A Case Report
Journal of Korean Dental Science
2022 .12
-
급성골수성백혈병의 차세대 염기서열 분석을 통한 분자유전학적 위험도 분류
대한내과학회지
2021 .12
-
Clinicopathological Implications of Mitochondrial Genome Alterations in Pediatric Acute Myeloid Leukemia
Annals of Laboratory Medicine
2016 .01
-
Recent Clinical Update of Acute Myeloid Leukemia: Focus on Epigenetic Therapies
Journal of Korean Medical Science
2021 .01
-
JAK2 V617F-Positive Acute Myeloid Leukemia: Clinicopathological Features of Two Cases
Laboratory Medicine Online
2022 .01
-
Spectrum of mitochondrial genome instability and implication of mitochondrial haplogroups in Korean patients with acute myeloid leukemia
Blood Research
2018 .01
-
Wild Carrot Oil Extract is Selectively Cytotoxic to Human Acute Myeloid Leukemia Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
HLA-DR과 CD34 음성인 급성골수성백혈병의 빈도 및 특징: 전형적 급성골수성백혈병과 급성전골수구백혈병 사이의 중간적 특질
Laboratory Medicine Online
2017 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0