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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 101 - 110 (10page)
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Background: To the best of our knowledge, the association between pediatric AML and mitochondrial aberrations has not been studied. We investigated various mitochondrial aberrations in pediatric AML and evaluated their impact on clinical outcomes.
Methods: Sequencing, mitochondrial DNA (mtDNA) copy number determination, mtDNA 4,977-bp large deletion assessments, and gene scan analyses were performed on the bone marrow mononuclear cells of 55 pediatric AML patients and on the peripheral blood mononuclear cells of 55 normal controls. Changes in the mitochondrial mass, mitochondrial membrane potential, and intracellular reactive oxygen species (ROS) levels were also examined.
Results: mtDNA copy numbers were about two-fold higher in pediatric AML cells than in controls (P<0.0001). Furthermore, a close relationship was found between mtDNA copy number tertiles and the risk of pediatric AML. Intracellular ROS levels, mitochondrial mass, and mitochondrial membrane potentials were all elevated in pediatric AML. The frequency of the mtDNA 4,977-bp large deletion was significantly higher (P< 0.01) in pediatric AML cells, and pediatric AML patients harboring high amount of mtDNA 4,977-bp deletions showed shorter overall survival and event-free survival rates, albeit without statistical significance.
Conclusions: The present findings demonstrate an association between mitochondrial genome alterations and the risk of pediatric AML.
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참고문헌 (39)
참고문헌 신청
Chinnery PF / 2003 / Mitochondria / J NeurolNeurosurgPsychiatry 74:1188~1199
DiMauro S / 2003 / Mitochondrial respiratory-chain diseases / NEngl J Med 348:2656~2668
Lim SW / 2012 / High‐frequency minisatellite instability of the mitochondrial genome in colorectal cancer tissue associated with clinicopathological values / Int J Cancer 131:1332~1341
Park SY / 2009 / Alteration of mitochondrial DNA sequence and copy number in nasal polyp tissue / Mitochondrion 9:318~325
Anderson S / 1981 / Sequence and organization of the human mitochondrial genome / Nature 290:457~465
DiMauro S / 2003 / Mitochondrial respiratory-chain diseases / NEngl J Med 348:2656~2668
Lim SW / 2012 / High‐frequency minisatellite instability of the mitochondrial genome in colorectal cancer tissue associated with clinicopathological values / Int J Cancer 131:1332~1341
Park SY / 2009 / Alteration of mitochondrial DNA sequence and copy number in nasal polyp tissue / Mitochondrion 9:318~325
Anderson S / 1981 / Sequence and organization of the human mitochondrial genome / Nature 290:457~465
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