지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Chromosomal abnormalities are an important prognostic factor in cases of acute myeloid leukemia (AML). Molecular mutations have been reported to contribute to the pathogenesis and prognosis of AML. Next-generation sequencing (NGS) has revolutionized the speed and cost of genomic sequencing and enables the parallel analysis of many genes for molecular risk stratification. The molecular mutations currently included in risk stratification at AML diagnosis are c-kit, FLT3-ITD, NPM1, CEBPA (biallelic), RUNX1, ASLX1, and TP53. The importance of screening for mutations has been further emphasized by introducing novel therapeutic targets for molecular mutations, such as FLT3-TKD, IDH1, and IDH2. Molecular mutations are also used to evaluate measurable residual disease during treatment and to select the intensity of the treatment during consolidation and follow-up. Pretreatment leukemic marrow and blood should be stored at a biobank to perform NGS analysis in cases of AML at diagnosis. Samples from various time points during and after treatment should be obtained and stored under appropriate conditions.
목차
등록된 정보가 없습니다.
참고문헌 (49)
참고문헌 신청
Eun-Hye Park / 2015 / Nationwide statistical analysis of myeloid malignancies in Korea: incidence and survival rate from 1999 to 2012 / Blood Research 50(4):204~217
Pollyea DA / 2021 / NCCN guidelines insights:acute myeloid leukemia, version 2.2021 / J Natl Compr Canc Netw 19:16~27
Döhner H / 2017 / Diagnosis and management of AML in adults : 2017 ELN recommendations from an international expert panel / Blood 129:424~447
김규표 / 2020 / 진료현장에서 정밀의료의 적용 / 대한내과학회지 95(6):382~386
박실비아 / 2020 / New agents in acute myeloid leukemia (AML) / Blood Research 55:14~18
Pollyea DA / 2021 / NCCN guidelines insights:acute myeloid leukemia, version 2.2021 / J Natl Compr Canc Netw 19:16~27
Döhner H / 2017 / Diagnosis and management of AML in adults : 2017 ELN recommendations from an international expert panel / Blood 129:424~447
김규표 / 2020 / 진료현장에서 정밀의료의 적용 / 대한내과학회지 95(6):382~386
박실비아 / 2020 / New agents in acute myeloid leukemia (AML) / Blood Research 55:14~18
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