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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 511 - 517 (7page)
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Background: Klotho protein plays a pivotal role in aging regulation. However, it is unclear whether klotho is expressed in human hair follicles and is correlated with hair growth. Objective: The purpose of this study was to determine the expression pattern and role of klotho in human hair follicles. Methods: We examined the klotho expression patterns in human hair follicles from young and aged donors. Furthermore, we examined the functional roles of klotho on human hair growth using klotho siRNA and klotho recombinant protein. Results: Interestingly, klotho was expressed in human hair follicles at both gene and protein levels. In hair follicles, prominent klotho expression was mainly observed in the outermost regions of the outer root sheath and hair bulb matrix cells. Quantification of klotho protein expression in young and aged donors showed that klotho expression decreased with aging. In human hair follicle organ culture, klotho silencing promoted premature catagen induction and inhibited human hair growth. Otherwise, klotho protein prolonged human hair growth. Conclusion: These results indicate that klotho might be an important regulatory factor for human hair growth and hair cycle change.
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참고문헌 (25)
참고문헌 신청
Stenn KS / 2001 / Controls of hair follicle cycling / Physiol Rev 81:449~494
Paus R / 1999 / The biology of hair follicles / N Engl J Med 341:491~497
Alonso L / 2006 / The hair cycle / J Cell Sci 119(Pt 3):391~393
Seok Yong Ahn / 2012 / Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B / Annals of Dermatology 24(1):26~31
Rishikaysh P / 2014 / Signaling involved in hair follicle morphogenesis and development / Int J Mol Sci 15:1647~1670
Paus R / 1999 / The biology of hair follicles / N Engl J Med 341:491~497
Alonso L / 2006 / The hair cycle / J Cell Sci 119(Pt 3):391~393
Seok Yong Ahn / 2012 / Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B / Annals of Dermatology 24(1):26~31
Rishikaysh P / 2014 / Signaling involved in hair follicle morphogenesis and development / Int J Mol Sci 15:1647~1670
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