지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 26 - 31 (6page)
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Background: Insulin-like growth factor-I (IGF-I) shares a high degree of structural and functional homology with insulin and is a potent mitogen supporting cell growth and survival in many kinds of the tissues and cells. It also plays a role in some differentiation and anti-apoptotic functions. In previous reports, it has been shown that IGF-I stimulates hair follicle (HF) growth, maintains the anagen stage, and postpones the catagen stage. Objective: The exact mechanism of the effect of IGF-I on HF growth is not yet established.
Therefore, we investigated the relationships between IGF-I and various other factors (i.e. apoptosis related molecules,pro-inflammatory cytokines, other growth factors, etc.) in the control of HF growth. Methods: The effect of IGF-I on human hair growth was measured using an organ culture model of human HFs and compared with a control group that did not receive IGF-I. We also measured mRNA expression of factors related to hair growth and apoptosis (which was determined by reverse transcription polymerase chain reaction (RT-PCR). RT-PCR was done on days 2, 4, 6, and 8 of organ culture. Results: In organ cultured human hair follicles, IGF-I had a positive effect on the rate of linear hair growth. IGF-I maintained the anagen phase. IGF-I increased the expression of platelet-derived growth factor (PDGF)-A, PDGF-B and the expression ratio of Bcl-2/Bax. Conclusion: The effect of IGF-I on hair growth appears to be related to the upregulation of PDGF-A and PDGF-B and to the anti-apoptotic effect of IGF-I.
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참고문헌 (23)
참고문헌 신청
Ben Amitai D / 2006 / I-GF-1 signalling controls the hair growth cycle and the differentiation of hair shafts / J Invest Dermatol 126 : 2135 ~
Bol DK / 1997 / Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice / Oncogene 14 : 1
Burgess W / 1999 / The immune-endocrine loop during aging: role of growth hormone and insulin-like growth factor-I / Neuroimmunomodulation 6 : 56 ~ 68
Hoffmann R / 1997 / Interleukin-1beta-induced inhibition of hair growth in vitro is mediated by cyclic AMP / J Invest Dermatol 108 : 40 ~ 42
Itami S / 2005 / Role of androgen in mesenchymal epithelial interactions in human hair follicle / J Investig Dermatol Symp Proc 10 : 209 ~ 211
Bol DK / 1997 / Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice / Oncogene 14 : 1
Burgess W / 1999 / The immune-endocrine loop during aging: role of growth hormone and insulin-like growth factor-I / Neuroimmunomodulation 6 : 56 ~ 68
Hoffmann R / 1997 / Interleukin-1beta-induced inhibition of hair growth in vitro is mediated by cyclic AMP / J Invest Dermatol 108 : 40 ~ 42
Itami S / 2005 / Role of androgen in mesenchymal epithelial interactions in human hair follicle / J Investig Dermatol Symp Proc 10 : 209 ~ 211
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