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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제19권 제1호
- 발행연도
- 2018.3
- 수록면
- 10 - 15 (6page)
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초록· 키워드
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In the present study, we investigated the expression patterns of p63, a member of the p53 gene family, in hair follicle cells at different stages of the hair cycle and examined the relation with cell proliferation activity. For this study, immunohistochemistry for p63 and Ki-67, a marker of cell proliferation, was performed in skin obtained from C3H/he mice with depilation. In the anagen stage, p63 was strongly expressed in the cells of bulge areas and epithelial strand, matrix cells of the hair bulbs and outer root sheath cells, but inner root sheath cells and dermal papilla cells were negative for p63. These expression patterns of p63 were similarly noted in hair follicles in the early catagen stage. In the late catagen and telogen stages of hair follicles, outer root sheath cells, seboblasts and duct cells were immunoreactive for p63. On the other hand, Ki-67-positive cells were selectively observed among the p63 positive cell components, although p63 positive cells were not always proliferative. Most of the matrix cells in the hair bulbs were positive for Ki-67. Ki-67-positive cells were also frequently evident in the cells of epithelial strands in the early anagen stage. Outer root sheath cells were often positive for Ki-67 in the anagen and early catagen stages, but very rare in the late catagen and telogen stages. In summary, p63 was expressed in the bulge stem cells, epithelial strand cells, matrix cells and outer root sheath cells of hair follicles at any stage of the cycle, which was associated with the movement of hair progenitor cells for regeneration. Ki-67-positive cells were evident among the p63-expressing cell components. Our results strongly suggest that p63 plays an important role in stem cell regulation, at least associated with cell proliferation, for the regeneration of hair follicles.
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참고문헌 (21)
참고문헌 신청
Koster MI / 2007 / Conflicting roles for p63 in skin development and carcinogenesis / Cell cycle 6:269~273
Koster MI / 2004 / p63 is the molecular switch for initiation of an epithelial stratification program / Genes Dev 18:126~131
Tsujita-Kyutoku M / 2003 / p63 expression in normal human epidermis and epidermal appendages and their tumors / J Cutan Pathol 30:11~17
Pellegrini G / 2001 / p63 identifies keratinocyte stem cells / Proc Natl Acad Sci USA 98:3156~3161
Muller-Rover S / 2001 / A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages / J Invest Dermatol 117:3~15
Koster MI / 2004 / p63 is the molecular switch for initiation of an epithelial stratification program / Genes Dev 18:126~131
Tsujita-Kyutoku M / 2003 / p63 expression in normal human epidermis and epidermal appendages and their tumors / J Cutan Pathol 30:11~17
Pellegrini G / 2001 / p63 identifies keratinocyte stem cells / Proc Natl Acad Sci USA 98:3156~3161
Muller-Rover S / 2001 / A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages / J Invest Dermatol 117:3~15
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