지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.98 No.6
- 발행연도
- 2020.6
- 수록면
- 332 - 339 (8page)
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Purpose: Klotho is an antiaging factor mainly produced by renal tubular cells. Klotho is reportedly decreased in an animal model of acute kidney injury and patients with chronic kidney disease. However, information on Klotho expression after kidney transplantation is limited. We analyzed the correlation between donor Klotho expression and clinical outcomes of kidney transplantation.
Methods: Sixty patients who underwent deceased donor kidney transplantation between March 2015 and October 2017 were enrolled. Serum and tissue Klotho expression levels were measured by enzyme-linked immunosorbent assay and immunohistochemistry, respectively. Graft function was assessed by estimated glomerular filtration rate (eGFR).
Results: Patients were divided into 2 groups according to donor Klotho expression in renal tissues. A greater improvement in eGFR was observed at 1 week after transplantation in patients receiving kidneys with higher Klotho expression (47.5 ± 21.9 mL/min/1.73 m² vs. 63.9 ± 28.2 mL/min/1.73 m², P = 0.030). Patients were also classified into 2 groups according to donor serum Klotho level. There was a tendency for a higher eGFR at 12 months after transplantation in patients receiving kidneys from donors with a higher Klotho level (51.0 ± 18.0 mL/min/1.73 m² vs. 61.2 ± 16.5 mL/min/1.73 m², P = 0.059). When subgrouped into patients with or without biopsy-proven acute rejection, 12-month eGFR remained higher in patients receiving kidneys from donors with higher serum Klotho.
Conclusion: Our data demonstrated that donor tissue expression of Klotho correlated with early recovery of eGFR after kidney transplantation. Donor serum Klotho level tended to be associated with posttransplant 12-month eGFR. Donor Klotho expression might be a new predictor for deceased donor kidney transplantation outcome.
Methods: Sixty patients who underwent deceased donor kidney transplantation between March 2015 and October 2017 were enrolled. Serum and tissue Klotho expression levels were measured by enzyme-linked immunosorbent assay and immunohistochemistry, respectively. Graft function was assessed by estimated glomerular filtration rate (eGFR).
Results: Patients were divided into 2 groups according to donor Klotho expression in renal tissues. A greater improvement in eGFR was observed at 1 week after transplantation in patients receiving kidneys with higher Klotho expression (47.5 ± 21.9 mL/min/1.73 m² vs. 63.9 ± 28.2 mL/min/1.73 m², P = 0.030). Patients were also classified into 2 groups according to donor serum Klotho level. There was a tendency for a higher eGFR at 12 months after transplantation in patients receiving kidneys from donors with a higher Klotho level (51.0 ± 18.0 mL/min/1.73 m² vs. 61.2 ± 16.5 mL/min/1.73 m², P = 0.059). When subgrouped into patients with or without biopsy-proven acute rejection, 12-month eGFR remained higher in patients receiving kidneys from donors with higher serum Klotho.
Conclusion: Our data demonstrated that donor tissue expression of Klotho correlated with early recovery of eGFR after kidney transplantation. Donor serum Klotho level tended to be associated with posttransplant 12-month eGFR. Donor Klotho expression might be a new predictor for deceased donor kidney transplantation outcome.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
Kuro-o M / 1997 / Mutation of the mouse klotho gene leads to a syndrome resembling ageing / Nature 390:45~51
Hu MC / 2013 / Renal and extrarenal actions of Klotho / Semin Nephrol 33:118~129
Olauson H / 2017 / Tissue expression and source of circulating αKlotho / Bone 100:19~35
Deng G / 2018 / Klotho : a promising biomarker closely related to kidney transplant / Exp Clin Transplant 16:253~258
Xu Y / 2015 / Molecular basis of Klotho : from gene to function in aging / Endocr Rev 36:174~193
Hu MC / 2013 / Renal and extrarenal actions of Klotho / Semin Nephrol 33:118~129
Olauson H / 2017 / Tissue expression and source of circulating αKlotho / Bone 100:19~35
Deng G / 2018 / Klotho : a promising biomarker closely related to kidney transplant / Exp Clin Transplant 16:253~258
Xu Y / 2015 / Molecular basis of Klotho : from gene to function in aging / Endocr Rev 36:174~193
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UCI(KEPA) : I410-ECN-0101-2020-514-000673080