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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 200 - 208 (9page)
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초록· 키워드
오류제보하기
Actinobacteria are prolific producers of a large number of natural products with diverse biological activities.
In the present study, an actinobacterium isolated from sunflower rhizosphere soil sample collected from Medak, Andhra Pradesh, South India was identified as Amycolatopsis thermoflava strain SFMA-103. A pigmented secondary metabolite in culture broth was extracted by using methanol and it was further purified by silica gel column chromatography with methanol-chloroform solvent system. Structural elucidation studies based on UV-visible, 1D and 2D-NMR, FT-IR, and mass spectroscopic analyses confirmed the structure as 1-methoxy-3-methyl-8-hydroxy-anthraquinone. It showed significant in vitro anticancer activity against lung cancer and lymphoblastic leukemia cells with IC50 values of 10.3 and 16.98 μM, respectively. In addition, 1-methoxy-3-methyl-8-hydroxy-anthraquinone showed good free radical scavenging activity by DPPH method with an EC50 of 18.2 μg/ml. It also showed other promising superoxide radical scavenging, nitric oxide radical scavenging and inhibition of lipid peroxidation activities. This is a first report of antiproliferative and antioxidant activities of 1-methoxy-3-methyl-8-hydroxy-anthraquinone isolated from A.
thermoflava strain SFMA-103 which may find potential application in biotechnological and pharmaceutical fields.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Adinarayana G / 2006 / Cytotoxic compounds from the marine actinobacterium Streptomyces corchorusii AUBN(1)/7 / Russ. J. Bioorg. Chem 32 : 295 ~ 300
Balachandran C / 2014 / Antimicrobial and cytotoxicity properties of 2,3-dihydroxy-9,10-anthraquinone isolated from Streptomyces galbus (ERINLG-127) / Appl. Biochem. Biotech
Balachandran C / 2016 / Isolation and characterization of 2-hydroxy-9,10-anthraquinone from Streptomyces olivochromogenes (ERINLG-261) with antimicrobial and antiproliferati
Bors W / 1990 / Flavonoids as antioxidants:determination of radical-scavenging efficiencies / Methods Enzymol 186 : 343 ~ 355
Byrstrykh LV / 1996 / Production of actinorhodinrelated “blue-pigments” by Streptomyces coelicolor A3(2) / J. Bacteriol 178 : 2238 ~ 2244
Balachandran C / 2014 / Antimicrobial and cytotoxicity properties of 2,3-dihydroxy-9,10-anthraquinone isolated from Streptomyces galbus (ERINLG-127) / Appl. Biochem. Biotech
Balachandran C / 2016 / Isolation and characterization of 2-hydroxy-9,10-anthraquinone from Streptomyces olivochromogenes (ERINLG-261) with antimicrobial and antiproliferati
Bors W / 1990 / Flavonoids as antioxidants:determination of radical-scavenging efficiencies / Methods Enzymol 186 : 343 ~ 355
Byrstrykh LV / 1996 / Production of actinorhodinrelated “blue-pigments” by Streptomyces coelicolor A3(2) / J. Bacteriol 178 : 2238 ~ 2244
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