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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제3호
- 발행연도
- 2020.1
- 수록면
- 398 - 403 (6page)
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Rhamnose is a naturally occurring deoxysugar present as a glycogenic component of plant and microbial natural products. A recombinant mutant Escherichia coli strain was developed by overexpressing genes involved in the TDP-L-rhamnose biosynthesis pathway of different bacterial strains and Saccharothrix espanaensis rhamnosyl transferase to conjugate intrinsic cytosolic TDP-L-rhamnose with anthraquinones supplemented exogenously. Among the five anthraquinones (alizarin, emodin, chrysazin, anthrarufin, and quinizarin) tested, quinizarin was biotransformed into a rhamoside derivative with the highest conversion ratio by whole cells of engineered E. coli. The quinizarin glycoside was identified by various chromatographic and spectroscopic analyses. The anti-proliferative property of the newly synthesized rhamnoside, quinizarin-4-O-α-L-rhamnoside, was assayed in various cancer cells.
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참고문헌 (28)
참고문헌 신청
Thomson RH / 1971 / Natural Occurring Quinones / Academic Press :367
Bien HS / 2005 / Ullmann's Encyclopedia of Industrial Chemistry / Wiley-VCH
Gordon PF / 1987 / Anthraquinone Dyes. Organic Chemistry in Colour / Springer
Agarwal S / 2000 / Antifungal activity of anthraquinone derivatives from Rheum emodi / J. Ethnopharmacol 72:43~46
Anton R / 1980 / Therapeutic use of natural anthraquinone for other than laxaive actions / Pharmacol. 20(Suppl. 1):104~112
Bien HS / 2005 / Ullmann's Encyclopedia of Industrial Chemistry / Wiley-VCH
Gordon PF / 1987 / Anthraquinone Dyes. Organic Chemistry in Colour / Springer
Agarwal S / 2000 / Antifungal activity of anthraquinone derivatives from Rheum emodi / J. Ethnopharmacol 72:43~46
Anton R / 1980 / Therapeutic use of natural anthraquinone for other than laxaive actions / Pharmacol. 20(Suppl. 1):104~112
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