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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제16권 제6호
- 발행연도
- 2006.1
- 수록면
- 880 - 888 (9page)
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초록· 키워드
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Pleurocidin, an α-helical cationic antimicrobialpeptide, was isolated from skin mucosa of winter flounder(Pleuronectes americanus). It had strong antimicrobial activitiesagainst Gram-positive and Gram-negative bacteria, but hadvery weak hemolytic activity. The Gly13,17→Ala analoghad dramatically increased hemolytic activity. The bacterialcel selectivity of pleurocidin was confirmed through themembrane-disrupting and membrane-binding affinities usingdye leakage, tryptophan fluorescence blue shift, and tryptophanquenching experiments. However, the non-cel-selectiveantimicrobial peptide, pleurocidin-AA, interacts strongly withboth negatively charged and zwitterionic phospholipid membranes,the latter of which are the major constituents of the outerleaflet of erythrocytes. Circular dihroism spectra showedthat pleurocidin-AA has much higher contents of α-helicalconformation than pleurocidin. The tertiary structure determinedby NMR spectroscopy showed that pleurocidin has a flexiblestructure between the long helix from Gly3 to Gly17 and theshort helix from Gly17 to Leu25. Cel-selective antimicrobialpeptide pleurocidin interacts strongly with negatively chargedphospholipid membranes, which mimic bacterial membranes.Structural flexibility between the two helices may play a keyrole in bacterial cel selectivity of pleurocidin.
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참고문헌 (22)
참고문헌 신청
Bax, A / 1985 / MLEV-17-based twodimensional homonuclear magnetization transfer spectroscopy / J. Magn. Reson. 65 : 355 ~ 360
Bax, A / 1985 / Practical aspects of twodimensional transverse NOE spectroscopy / J. Magn. Reson. 63 : 207 ~ 213
Baxter, N. J / 1997 / Temperature dependence of 1H chemical shifts in proteins. / J. Biomol. NMR 9 : 359 ~ 369
Brunger, A. T / 1993 / X-PLOR Manual, Version 3.1 / Yale University, New Haven, CT.
Clore, G. M / 1987 / Three-dimensional structure of potato carboxypeptidase inhibitor in solution. A study using nuclear magnetic resonance, distance geometry, and restrained
Bax, A / 1985 / Practical aspects of twodimensional transverse NOE spectroscopy / J. Magn. Reson. 63 : 207 ~ 213
Baxter, N. J / 1997 / Temperature dependence of 1H chemical shifts in proteins. / J. Biomol. NMR 9 : 359 ~ 369
Brunger, A. T / 1993 / X-PLOR Manual, Version 3.1 / Yale University, New Haven, CT.
Clore, G. M / 1987 / Three-dimensional structure of potato carboxypeptidase inhibitor in solution. A study using nuclear magnetic resonance, distance geometry, and restrained
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