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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 19 - 23 (5page)
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Recently, marine organisms are emerging as a leading group for identifying and extracting novel bioactive substances. These substances are known to possess a potential regarding not only as a source of pharmaceutical products but also their beneficial effects on humans.
Among the substances, antimicrobial peptides (AMPs) specifically have attracted considerable interest for possible use in the development of new antibiotics. AMPs are characterized by relatively short cationic peptides containing the ability to adopt a structure in which cationic or hydrophobic amino acids are spatially scattered. Although a few reports address novel marine organisms-derived AMPs, their antimicrobial mechanism(s) are still remain unknown. In this review, we summarized the peptides previously investigated, such as Pleurocidin, Urechistachykinins, Piscidins and Arenicin-1. These peptides exhibited significant antimicrobial activities against human microbial pathogens without remarkable hemolytic effects against human erythrocytes,and their mode of actions are based on permeabilization of the plasma membrane of the pathogen.
Therefore, the study of antimicrobial peptides derived from marine organisms may prove to be useful in the design of future therapeutic antimicrobial drugs.
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참고문헌 (22)
참고문헌 신청
Brogden,K.A / 2005 / Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? / Nat. Microbial. Rev. 3 : 238 ~ 250
Cohen,M.L / 1992 / Epidemiology of drug resistance; implications for a post-antimicrobial era / Science 257 : 1050 ~ 1055
Cole, A. M / 1997 / Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder / J. Biol. Chem. 272 : 12008 ~ 12013
Donia, M / 2003 / Marine natural products and their potential applications as anti-infective agents / Lancet Infect Dis. 3 : 338 ~ 348
Haefner,B / 2003 / Drugs from the deep: marine natural products as drug candidates / Drug Discov. Today 8 : 536 ~ 544
Cohen,M.L / 1992 / Epidemiology of drug resistance; implications for a post-antimicrobial era / Science 257 : 1050 ~ 1055
Cole, A. M / 1997 / Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder / J. Biol. Chem. 272 : 12008 ~ 12013
Donia, M / 2003 / Marine natural products and their potential applications as anti-infective agents / Lancet Infect Dis. 3 : 338 ~ 348
Haefner,B / 2003 / Drugs from the deep: marine natural products as drug candidates / Drug Discov. Today 8 : 536 ~ 544
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