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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제8호
- 발행연도
- 2018.1
- 수록면
- 1,299 - 1,309 (11page)
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초록· 키워드
오류제보하기
We previously reported on lactophoricin (LPcin), a cationic α-helical antimicrobial peptide derived from bovine milk, which has antimicrobial effects on Candida albicans as well as Grampositive and Gram-negative bacteria. In this study, we designed the LPcin-YK3 peptide, a shorter analog of LPcin, and investigated its antimicrobial activity. This peptide, consisting of 15 amino acids with + 3 net charges, was an effective antimicrobial agent against the on the Gram-positive strain, Staphylococcus aureus (MIC: 0.62 μg/ml). In addition, the hemolytic activity assay revealed that the peptide was not toxic to mouse and human erythrocytes up to 40 μg/ml. We also used circular dichroism spectroscopy to confirm that peptide in the presence of lipid has α-helical structures and later provide an overview of the relationship between each structure and antimicrobial activity. This peptide is a member of a new class of antimicrobial agents that could potentially overcome the problem of bacterial resistance caused by overuse of conventional antibiotics. Therefore, it could be used as a therapeutic or natural additive, particularly in the cosmetics industry.
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참고문헌 (34)
참고문헌 신청
Brogden KA / 2005 / Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? / Nat. Rev. Microbiol. 3:238~250
Liu Y / 2000 / Purification, characterization, and molecular cloning of the gene of a seed-specific antimicrobial protein from pokeweed / Plant Physiol. 122:1015~1024
Chernysh S / 2002 / Antiviral and antitumor peptides from insects / Proc. Natl. Acad. Sci. USA 99:12628~12632
Hancock RE / 2006 / Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies / Nat. Biotechnol. 24:1551~1557
Zasloff M / 2002 / Antimicrobial peptides of multicellular organisms / Nature 415:389~395
Liu Y / 2000 / Purification, characterization, and molecular cloning of the gene of a seed-specific antimicrobial protein from pokeweed / Plant Physiol. 122:1015~1024
Chernysh S / 2002 / Antiviral and antitumor peptides from insects / Proc. Natl. Acad. Sci. USA 99:12628~12632
Hancock RE / 2006 / Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies / Nat. Biotechnol. 24:1551~1557
Zasloff M / 2002 / Antimicrobial peptides of multicellular organisms / Nature 415:389~395
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