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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국미생물생명공학회 한국미생물·생명공학회지 한국미생물·생명공학회지 제37권 제2호
발행연도
2009.1
수록면
160 - 169 (10page)

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Poly-γ-glutamic acid (γ-PGA) was mixed natural flora of Bacillus subtilis, contaminated from cooked soybeans. Also, it was performed to find out the antiallergic activity by using NC/ Nga mice, in vitro. The γ-PGA (PGA-HM : PGA-high molecular weight), Molecular weight 300 kDa, was decomposed and made PGA-LM (PGA-low molecular weight) which has molecular weight below 30 kDa by sonication. Therefore, it was same result between PGA-HM and PGA-LM, and reported PGA-LM as basic result. We found that PGA-LM contains antiallergic efficacy that inhibit B cells and Th2 cells activation from isolated CD4+ T cells in NC/Nga atopic dermatitis model mice, and not show a cytotoxicity in the hFCs. To investigate the effects of these PGA-LM in vitro, isolation of splenic B cell and CD4+ T cells in atopic dermatitis mice were used. To elucidate the role of PGA-LM in anti-CD40+ interleukin-4 (IL-4)-mediated B-cell activation, showed that the capacity of B cells to expression IL-1β, IL-6, and TNF-α mRNA down-regulated, and IL-10 mRNA up-regulation by PGA-LM treatment, but it had no effect on TGF-β expression. In addition to CD4+IFN-γ+ and CD4+CD25+foxp3+, the functions of PGA-LM in the development of the CD4+ CD25+foxp3+ and CD4+IFN-γ+ cells, the phenotype and functions of PGA-LM induced CD4+CD25+ foxp3+, and CD4+IFN-γ+ cells in CD4+ T cells. These results suggested that PGA-LM could change cytokine production and generate CD4+CD25+foxp3+ Tregs in NC/Nga mice, and may be effective for immunotherapy in patients with AD.

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