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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 203 - 210 (8page)
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초록· 키워드
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Cycloxygenase (COX) is a key enzyme in the con-version of arachidonic acid into prostanoids which participate in various cellular functions including apoptosis, mitogenesis, inflammation, imune mod-ulation and diferentiation. Moreover, the synthetic glucocorticoid, dexamethasone has imune mod-ulating and anti-inflamatory effects in vivo. Re-cently, dexamethasone was found to enhance re-study, we investigated the mechanisms of dexa-methasone-mediated neuronal diferentiation. Im-munobloting and morphological analysis demon-strated that dexamethasone induced neuronal dif-ferentiation through COX 1 induction. This pheno-menon was inhibited by indomethacin, a COX inhibitor. In addition, the adition of exogenous prostaglandin E2 (PGE2), a substance produced by the COX-mediated pathway, triggered neurite out-growth of cels treated with COX inhibitor. Taken in dexamethasone-mediated neuronal diferentia-tion.
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