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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 536 - 544 (9page)
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It has been proposed that the pro-inflammatory catalytic activity of cyclooxygenase-2 (COX-2) plays a key role in the aging process. However, it remains unclear whether the COX-2 activity is a causal factor for aging and whether COX-2 inhibitors could prevent aging. We here examined the effect of COX-2 inhibitors on aging in the intrinsic skin aging model of hairless mice. We observed that among two selective COX-2inhibitors and one non-selective COX inhibitor studied, only NS-398 inhibited skin aging, while celecoxib and aspirin accelerated skin aging. In addition, NS-398 reduced the expression of p53 and p16, whereas celecoxib and aspirin enhanced their expression. We also found that the aging-modulating effect of the inhibitors is closely associated with the expression of type I procollagen and caveolin-1. These results suggest that pro-inflammatory catalytic activity of COX-2 is not a causal factor for aging at least in skin and that COX-2 inhibitors might modulate skin aging by regulating the expression of type I procollagen and caveolin-1.
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참고문헌 (24)
참고문헌 신청
Alcorta DA / 1996 / Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts / Proc Natl Acad Sci USA 93 : 13742
Atadja P / 1995 / Increased activity of p53 in senescing fibroblasts / Proc Natl Acad Sci USA 92 : 8348 ~ 8352
Baek BS / 2001 / Age-related increase of brain cyclooxygenase activity and dietary modulation of oxidative status / J Gerontol A Biol Sci Med Sci 56 : B426 ~ B431
Barnett J / 1994 / Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system / Biochim Biophys A
Bartholomew JN / 2009 / Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel Mdm2/p53-mediated pathway / Cancer Res 69 : 2878 ~
Atadja P / 1995 / Increased activity of p53 in senescing fibroblasts / Proc Natl Acad Sci USA 92 : 8348 ~ 8352
Baek BS / 2001 / Age-related increase of brain cyclooxygenase activity and dietary modulation of oxidative status / J Gerontol A Biol Sci Med Sci 56 : B426 ~ B431
Barnett J / 1994 / Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system / Biochim Biophys A
Bartholomew JN / 2009 / Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel Mdm2/p53-mediated pathway / Cancer Res 69 : 2878 ~
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