지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 199 - 203 (5page)
이용수
초록· 키워드
오류제보하기
Cyclooxygenase-2 (COX-2) has been reported to be associated with tumor development and pro-tosis induced by various cellular stresses. Th-rough a tetracycline-regulated COX-2 overexpres-sion system, we found that COX-2 inhibits de-tachment-induced apoptosis (anoikis) in a human bladder cancer cel line, EJ. We also found that the inhibition of anoikis by COX-2 results from activation of the PI-3K/Akt pathway as evidenced by suppresion of the COX-2 efect on anoikis by a PI-3K inhibitor, LY294002. Furthermore, COX-2 enhanced Mcl-1 expression in the anoikis pro-cess, implying that Mcl-1 also may be involved in mediating the survival function of COX-2. To-anoikis by activation of the PI-3K/Akt pathway and probably by enhancement of Mcl-1 expres-sion in human blader cancer cells. This anti- anoikis effect of COX-2 may be a part of mech-anisms to promote tumor development and pro-gression.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
/ / -nitrosamine-induced urinary bladdercancers in male B6D2F1 mice and female Fischer-344rats : 4 5599 ~ 602
/ / Cyclooxygenase 2 promotes cell survival bystimulation of dynein light chain expression and inhibition ofneuronal nitric oxide synthase activity : 8571 ~ 9
/ / Cyclooxygenase-2 overexpression inhibits death receptor 5expression and confers resistance to tumor necrosis factorrelatedapoptosis-inducing ligand-induced apoptosis in
/ / Hepatocyte growth factorinhibits anoikis by induction of activator protein 1-dependentcyclooxygenase-2 Implication in head and neck squamouscell carcinoma progression :
/ / Integrins and anoikis integrins and a (ikis) : 701 ~ 6
/ / Cyclooxygenase 2 promotes cell survival bystimulation of dynein light chain expression and inhibition ofneuronal nitric oxide synthase activity : 8571 ~ 9
/ / Cyclooxygenase-2 overexpression inhibits death receptor 5expression and confers resistance to tumor necrosis factorrelatedapoptosis-inducing ligand-induced apoptosis in
/ / Hepatocyte growth factorinhibits anoikis by induction of activator protein 1-dependentcyclooxygenase-2 Implication in head and neck squamouscell carcinoma progression :
/ / Integrins and anoikis integrins and a (ikis) : 701 ~ 6
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Gallotannin regulates apoptosis and COX-2 expression via Akt and p38kinase pathway in human lung cancer cell line, A549
Animal cells and systems
2012 .01
-
Cyclooxygenase-2 promotes cell proliferation, migration andinvasion in U2OS human osteosarcoma cells
Experimental and Molecular Medicine
2007 .01
-
HT-29 대장암세포에서 Akt 활성 저해에 따른 셀레늄의 세포 증식억제 효과
생명과학회지
2012 .01
-
Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner
Experimental and Molecular Medicine
2012 .01
-
Rottlerin enhances IL-1β-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells
Experimental and Molecular Medicine
2011 .01
-
돌돔, Oplegnathus fasciatus의 Cyclooxygenase-2 유전자의 cloning 및 발현분석
한국어병학회지
2013 .01
-
Ectopic expression of cyclooxygenase-2-induced dedifferentiation in articular chondrocytes
Experimental and Molecular Medicine
2008 .01
-
Induction of p53-dependent Apoptosis by Resveratrol in Human Cancer Cells, A549 and SKOV3
한국미생물·생명공학회지
2016 .01
-
위암에서 종양관련 단백질들과 COX-2 발현의 상관성
대한임상검사과학회지
2007 .01
-
A549 폐암세포에서 미토콘드리아 경로를 통한 개똥쑥 추출물의 apoptosis 유도 효과
생명과학회지
2016 .08
-
Thymoquinone (TQ) regulates cyclooxygenase-2 expression and prostaglandin E2 production through PI3kinase (PI3K)/p38 kinase pathway in human breast cancer cell line, MDA-MB-231
Animal cells and systems
2012 .01
-
AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin
Experimental and Molecular Medicine
2009 .01
-
Box-Cox Transformation for Conditional Heteroscedasticity in Domestic Financial Time Series
한국데이터정보과학회지
2004 .06
-
A Robust Modified Cox Test for Time Series Models
Journal of The Korean Data Analysis Society
2005 .01
-
New insights into the functions of Cox-2 in skin and esophageal malignancies
Experimental and Molecular Medicine
2020 .01
-
Apoptotic Effects of Resveratrol via mTOR and COX-2 Signal Pathways in MCF-7 Breast Cancer Cells
생명과학회지
2011 .09
-
Cyclooxygenase (COX)- 2 Is Regulated by Progesterone and Estrogen in the Rat Uterine Cell Line
한국동물학회 학술대회
2000 .01
-
Potent Anti-influenza Effects of Novel mPGES-1 Inhibitors Mediated by Inhibition of PI3K/AKT Signaling Pathway and Pro-inflammatory Gene Expression
한국미생물학회 학술대회논문집
2015 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0