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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 469 - 476 (8page)
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초록· 키워드
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Osteosarcoma is the most comon primary bone tu-mor, but the pathogenesis is not well understood. While cyclooxygeanse-2 (COX-2) is known to be close-ly associated with tumor growth and metastasis in sev-eral kinds of human tumors, the function of COX-2 in osteosarcoma is unclear. Therefore, to investigate the function of COX-2 in osteosarcoma, we established stable cell lines overexpressing COX-2 in U2OS human
osteosarcoma cells. COX-2 overexpression as well as
prostaglandin E2 treatment promoted proliferation of
U2OS cells. In addition, COX-2 overexpression enhanced
mobility and invasiveness of U2OS cells,
which was accompanied by increases of matrix metalloproteinase-
2 and -9 (MMP-2 and -9) activities. Selective
COX-2 inhibitors, NS-398 and celecoxib, inhibited
cell proliferation and abrogated the enhanced mobility,
invasiveness and MMP activities induced by COX-2
overexpression. These results suggest that COX-2 is
directly associated with cell proliferation, migrationand invasion in human osteosarcoma cells, and the
therapeutic value of COX-2 inhibitors should be evaluated
continuously.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
/ 2001 / cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice 276 : 18563 ~ 18569
Castellone MD / 2005 / Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-β-catenin signaling axis 310 : 1504 ~ 1510
Chen Q / 2004 / Significance of COX-2 expression in human renal cell carcinoma cell lines 108 ( ) : 825 ~ 832
Davies KJ / 1999 / The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress 48 : 41 ~ 47
Dickens DS / 2002 / Cyclooxygenase-2 expression in pediatric sarcomas 5 : 356 ~ 364
Castellone MD / 2005 / Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-β-catenin signaling axis 310 : 1504 ~ 1510
Chen Q / 2004 / Significance of COX-2 expression in human renal cell carcinoma cell lines 108 ( ) : 825 ~ 832
Davies KJ / 1999 / The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress 48 : 41 ~ 47
Dickens DS / 2002 / Cyclooxygenase-2 expression in pediatric sarcomas 5 : 356 ~ 364
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