지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 387 - 396 (10page)
이용수
초록· 키워드
오류제보하기
Angiotensin II (Ang II) stimulates migration of vascular smooth muscle cell (VSMC) in addition to its contribution to contraction and hypertrophy. It is well established that Rho GTPases regulate cellular contractility and migration by reorganizing the actin cytoskeleton. Ang II activates Rac1 GTPase, but its upstream guanine nucleotide exchange factor (GEF) remains elusive. Here, we show that Ang II-induced VSMC migration occurs in a βPIX GEF-dependent manner. βPIX-specific siRNA treatment significantly inhibited Ang II-induced VSMC migration. Ang II activated the catalytic activity of βPIX towards Rac1 in dose- and time-dependent manners. Activity reached a peak at 10 min and declined close to a basal level by 30 min following stimulation. Pharmacological inhibition with specific kinase inhibitors revealed the participation of protein kinase C, Src family kinase, and phosphatidylinositol 3-kinase (PI3-K) upstream of βPIX. Both p21-activated kinase and reactive oxygen species played key roles in cytoskeletal reorganization downstream of βPIX-Rac1. Taken together, our results suggest that βPIX is involved in Ang II-induced VSMC migration.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Cau J / 2005 / Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways / J Cell Sci 118 : 2579 ~ 2587
Chamley-Campbell J / 1979 / The smooth muscle cell in culture / Physiol Rev 59 : 1 ~ 61
Chang F / 2007 / FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX / Mol Biol Cell 18 : 253 ~ 264
Cheng G / 2006 / Nox1-dependent reactive oxygen generation is regulated by Rac1 / J Biol Chem 281 : 17718 ~ 17726
Gao Y / 2004 / Rational design and characterization of a Rac GTPase-specific small molecule inhibitor / Proc Natl Acad Sci USA 101 : 7618 ~ 7623
Chamley-Campbell J / 1979 / The smooth muscle cell in culture / Physiol Rev 59 : 1 ~ 61
Chang F / 2007 / FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX / Mol Biol Cell 18 : 253 ~ 264
Cheng G / 2006 / Nox1-dependent reactive oxygen generation is regulated by Rac1 / J Biol Chem 281 : 17718 ~ 17726
Gao Y / 2004 / Rational design and characterization of a Rac GTPase-specific small molecule inhibitor / Proc Natl Acad Sci USA 101 : 7618 ~ 7623
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Inhibitory effect of Hsp70 on angiotensin II-induced vascular smooth muscle cell hypertrophy
Experimental and Molecular Medicine
2006 .01
-
Loss of βPix Causes Defects in Early Embryonic Development, and Cell Spreading and PlateletDerived Growth Factor-Induced Chemotaxis in Mouse Embryonic Fibroblasts
Molecules and Cells
2019 .01
-
βPAK-interacting exchange factor may regulate actin cytoskeleton through interaction with actin
Experimental and Molecular Medicine
2004 .01
-
Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway
Experimental and Molecular Medicine
2006 .01
-
Molecular Cloning and Characterization of a Novel Mouse $\beta$ Pix Isoform
한국동물학회 학술대회
2001 .01
-
βig-h3 triggers signaling pathways mediating adhesion and migration of vascular smooth muscle cells through αvβ5 integrin
Experimental and Molecular Medicine
2006 .01
-
Studies on the Identification of Pythium spp. and Sclerotial Fungi isolated from Rice plants in Korea (II)
한국균학회지
1978 .01
-
Orphan nuclear receptor small heterodimer partner inhibits angiotensin II- stimulated PAI-1 expression in vascular smooth muscle cells
Experimental and Molecular Medicine
2010 .01
-
Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro
Experimental and Molecular Medicine
2009 .01
-
Sodium tanshinone IIA sulfonate depresses angiotensin IIinducedcardiomyocyte hypertrophy through MEK/ERKpathway
Experimental and Molecular Medicine
2007 .01
-
Knockdown of lncRNA PVT1 Inhibits Vascular Smooth Muscle Cell Apoptosis and Extracellular Matrix Disruption in a Murine Abdominal Aortic Aneurysm Model
Molecules and Cells
2019 .01
-
Heat shock protein 90 regulates IκB kinase complex and NF-κB activation in angiotensin II-induced cardiac cell hypertrophy
Experimental and Molecular Medicine
2010 .01
-
Synergistic induction of cancer cell migration regulated by Gβγ and phosphatidylinositol 3-kinase
Experimental and Molecular Medicine
2012 .01
-
The p38 mitogen-activated protein kinase is involved in stress-induced phospholipase D activation in vascular smooth muscle cells
Experimental and Molecular Medicine
2002 .01
-
Artemisinin attenuates platelet-derived growth factor BB-induced migration of vascular smooth muscle cells
Nutrition Research and Practice
2014 .10
-
Artemisinin attenuates platelet-derived growth factor BB-induced migration of vascular smooth muscle cells
Nutrition Research and Practice
2014 .10
-
NF-κB-responsive miR-155 induces functional impairment of vascular smooth muscle cells by downregulating soluble guanylyl cyclase
Experimental and Molecular Medicine
2019 .01
-
Angiopoietin-1 variant, COMP-Ang1 attenuates hydrogenperoxide-induced acute lung injury
Experimental and Molecular Medicine
2008 .01
-
The role of Rho GTPases in the regulation of the rearrangement of actin cytoskeleton and cell movement
Experimental and Molecular Medicine
2004 .01
-
$\beta$ Pix binds dynamin GTPase though SH3 domain : A role in the regulation of the function of dynamin by phosphorylation
한국동물학회 학술대회
2001 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0