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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 508 - 516 (9page)
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초록· 키워드
오류제보하기
Cardiac fibrosis occurs after pathological stimuli to the
cardiovascular system. One of the most important factors
that contribute to cardiac fibrosis is angiotensin
II (Ang II). Accumulating studies have suggested that
reactive oxygen species (ROS) plays an important
role in cardiac fibrosis and sodium tanshinone IIA
sulfonate (STS) possesses antioxidant action. We
therefore examined whether STS depresses Ang
II-induced collagen type I expression in cardiac
fibroblasts. In this study, Ang II significantly enhanced
collagen type I expression and collagen
synthesis. Meanwhile, Ang II depressed matrix metalloproteinase-
1 (MMP-1) expression and activity.
These responses were attenuated by STS. Furthermore,
STS depressed the intracellular generation of
ROS, NADPH oxidase activity and subunit p47phox
expression. In addition, N-acetylcysteine the ROS
scavenger, depressed effects of Ang II in a manner
similar to STS. In conclusion, the current studies
demonstrate that anti-fibrotic effects of STS are
mediated by interfering with the modulation of ROS.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Ashizawa N / 1996 / Osteopontin is produced by rat cardiac fibroblasts and mediates A(II)-induced DNA synthesis and collagen gel contraction / J Clin Invest 98 : 2218 ~ 2227
Brilla CG / 1994 / Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone / J Mol Cell Cardiol 26 : 809 ~ 820
Brown L / 2005 / Cardiac extracellular matrix: a dynamic entity / Am J Physiol Heart Circ Physiol 289 : 973 ~ 974
Brown RD / 2007 / Cytokines regulate matrix metalloproteinases and migration in cardiac fibroblasts / Biochem Biophys Res Commun 362 : 200 ~ 205
Chen J / 2006 / Angiotensin II-mediated oxidative stress and procollagen-1 expression in cardiac fibroblasts: blockade by pravastatin and pioglitazone / Am J Physiol Heart Ci
Brilla CG / 1994 / Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone / J Mol Cell Cardiol 26 : 809 ~ 820
Brown L / 2005 / Cardiac extracellular matrix: a dynamic entity / Am J Physiol Heart Circ Physiol 289 : 973 ~ 974
Brown RD / 2007 / Cytokines regulate matrix metalloproteinases and migration in cardiac fibroblasts / Biochem Biophys Res Commun 362 : 200 ~ 205
Chen J / 2006 / Angiotensin II-mediated oxidative stress and procollagen-1 expression in cardiac fibroblasts: blockade by pravastatin and pioglitazone / Am J Physiol Heart Ci
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