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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 21 - 29 (9page)
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Angiotensin II is a major effector molecule in the development of cardiovascular disease. In vascular smooth muscle cells (VSMCs), angiotensin II promotes cellular proliferation and extracellular matrix accumulation through the upregulation of plasminogen activator inhibitor-1 (PAI-1) expression. Previously, we demonstrated that small heterodimer partner (SHP) represses PAI-1 expression in the liver through the inhibition of TGF-β signaling pathways. Here, we investigated whether SHP inhibited angiotensin II-stimulated PAI-1expression in VSMCs. Adenovirus-mediated overexpression of SHP (Ad- SHP) in VSMCs inhibited angiotensin II- and TGF-β-stimulated PAI-1 expression.
Ad-SHP also inhibited angiotensin II-, TGF-β- and Smad3-stimulated PAI-1 promoter activity, and angiotensin II-stimulated AP-1 activity. The level of PAI-1 expression was significantly higher in VSMCs of SHP-/-mice than wild type mice. Moreover, loss of SHP increased PAI-1 mRNA expression after angiotensin II treatment. These results suggest that SHP inhibits PAI-1 expression in VSMCs through the suppression of TGF-β/Smad3 and AP-1 activity. Thus, agents that target the induction of SHP expression in VSMCs might help prevent the development and progression of atherosclerosis.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Ahn JD / 2001 / Transcription factor decoy for activator protein-1 (AP-1) inhibits high glucose- and angiotensin II-induced type 1 plasminogen activator inhibitor (PAI-1) gen
Ahn JD / 2002 / Inhibitory effects of novel AP-1 decoy oligodeoxynucleotides on vascular smooth muscle cell proliferation in vitro and neointimal formation in vivo / Circ Res
Binder BR / 2002 / Plasminogen Activator Inhibitor 1: Physiological and Pathophysiological Roles / News Physiol Sci 17 : 56 ~ 61
Brendel C / 2002 / The small heterodimer partner interacts with the liver X receptor α and represses its transcriptional activity / Mol Endocrinol 16 : 2065 ~ 2076
Chen HC / 2004 / MEK1,2 response element mediates angiotensin II-stimulated plasminogen activator inhibitor-1 promoter activation / Blood 103 : 2636 ~ 2644
Ahn JD / 2002 / Inhibitory effects of novel AP-1 decoy oligodeoxynucleotides on vascular smooth muscle cell proliferation in vitro and neointimal formation in vivo / Circ Res
Binder BR / 2002 / Plasminogen Activator Inhibitor 1: Physiological and Pathophysiological Roles / News Physiol Sci 17 : 56 ~ 61
Brendel C / 2002 / The small heterodimer partner interacts with the liver X receptor α and represses its transcriptional activity / Mol Endocrinol 16 : 2065 ~ 2076
Chen HC / 2004 / MEK1,2 response element mediates angiotensin II-stimulated plasminogen activator inhibitor-1 promoter activation / Blood 103 : 2636 ~ 2644
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