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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 320 - 331 (12page)
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초록· 키워드
오류제보하기
Reactive oxygen species (ROS) play a crucial role in
acute lung injury. Tissue inflammation, the increased
vascular permeability, and plasma exudation are cardinal
features of acute lung injury. Angiopoietin-1 (Ang1)
has potential therapeutic applications in preventing
vascular leakage and also has beneficial effects in several
inflammatory disorders. Recently developed
COMP-Ang1 is more potent than native Ang1 in phosphorylating
tyrosine kinase with immunoglobulin and
EGF homology domain 2 receptor in endothelial cells.
However, there are no data on effects and related molecular
mechanisms of COMP- Ang1 on ROS-induced
acute lung injury. We used hydrogen peroxide
(H2O2)-inhaled mice to evaluate the effect of
COMP-Ang1 on pulmonary inflammation, bronchial
hyper-responsiveness, and vascular leakage in acute
lung injury. The results have revealed that VEGF expression,
the levels of IL-4, TNF-α, IL-1β, intercellular
adhesion molecule-1, and vascular cell adhesion molecule-
1 in lungs, the levels of hypoxia-inducible factor-
1α (HIF-1α) and NF-κB in nuclear protein extracts,
phosphorylation of Akt, and vascular permeability
were increased after inhalation of H2O2 and that the administration
of COMP-Ang1 markedly reduced airway
hyper-responsiveness, pulmonary inflammation,
plasma extravasation, and the increases of cytokines,
adhesion molecules, and VEGF in lungs treated with
H2O2. We have also found that the activation of HIF-1α
and NF-κB and the increase of phosphoinositide 3-kinase
activity in lung tissues after H2O2 inhalation were
decreased by the administration of COMP-Ang1.
These results suggest that COMP-Ang1 ameliorates
ROS-induced acute lung injury through attenuating
vascular leakage and modulating inflammatory
mediators.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Baffert F / 2006 / Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules / Am J Physiol Heart Circ Physiol 290 : 107 ~ 18
Barnes PJ / 1997 / Nuclear factor-κB - a pivotal transcription factor in chronic inflammatory diseases / N Engl J Med 336 : 1066 ~ 71
Chae JK / 2000 / Coadministration of angiopoietin-1 and vascular endothelial growth factor enhances collateral vascularization / Arterioscler Thromb Vasc Biol 2 : 2573 ~ 8
Chandel NS / 2000 / Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia / J Biol Chem 275 : 25130 ~ 8
Cho CH / 2004 / COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity / Proc Natl Acad Sci USA 101 : 5547 ~ 52
Barnes PJ / 1997 / Nuclear factor-κB - a pivotal transcription factor in chronic inflammatory diseases / N Engl J Med 336 : 1066 ~ 71
Chae JK / 2000 / Coadministration of angiopoietin-1 and vascular endothelial growth factor enhances collateral vascularization / Arterioscler Thromb Vasc Biol 2 : 2573 ~ 8
Chandel NS / 2000 / Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia / J Biol Chem 275 : 25130 ~ 8
Cho CH / 2004 / COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity / Proc Natl Acad Sci USA 101 : 5547 ~ 52
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