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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 448 - 453 (6page)
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Breast cancer susceptibility gene, BRCA2, is a tumor supressor and individuals who inherit one defected copy of BRCA2onset breast cancer or ovarian cancer accom-panied by the los of the wild type allele. Mouse model for Brca2 mutation shows growth retarda-tion and paradoxical occurence of thymic lympho-mas. Thymic lymphomas from Brca2-mutant mice harbor mutations in p53, Bub1, and BubR1, which function as mitotic checkpoint proteins. Therefore, interplay betwen Brca2 and mitotic checkpoint has been suggested in the maintenance of genetic fidelity, although it has not ben asesed whe-ther the unique mutations in Bub1 and BubR1 found in Brca2-mutant mice are responsible for the abolishment of mitotic checkpoint function. This report demonstrates that Bub1 and BubR1 mutant proteins from Brca2-/-thymic lymphomas have defects in the phosphorylation and kineto-chore localization after spindle damage. Thus, the mutations of Bub1 and BubR1 found in Brca2- mutant mice indeed are responsible for the chro-mosome instability in Brca2-mutated tumors.
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