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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 508 - 513 (6page)
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Failure of mitotic checkpoint machinery leads to the chromosomal missegregation and nuclear endore-duplication, thereby driving the emergence of aneu-ploidy and tetraploidy population. Although abnormal nuclear ploidy and the resulting impairment of mitotic checkpoint function are typical physiological event leading to human hepatocellular carcinoma, any muta-tional change of mitotic checkpoint regulators has not yet been discovered. Therefore, we investigated the mutation of p31comet, a recently identified mitotic check-point regulator, in human hepatocellular carcinoma. Of 51 human hepatocellular carcinoma tissue and 6 cell lines tested, five samples exhibited nucleotide se-quence variations dispersed on four sites within the entire coding sequence. Among these sites with se-quence substitutions, three were found to be missense mutation accompanied with amino acid change but one was a silent mutation. Of these sequence sub-stitutions, two were present in both tumor and non-tu-mor liver tissues, suggesting the posibility of polymorphism. The present findings indicate that p31cometdoes not have an impact on the formation of aneuploidy and tetraploidy found in human hepatocel-lular carcinoma.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Baker DJ / 2004 / BubR1 insuficiency causes early onset of aging-associated phenotypes and infertility in mice 36 : 744 ~ 749
Cytogenet Cell Genet 1983;36 / / Catalogue of chromosome aberrations in cancer : 1 ~ 515
Fang G / 1998 / The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation 12 : 187
Feitelson MA / 1999 / Hepatitis B virus in hepatocarcinogenesis 181 : 188 ~ 202
Gemma A / 2001 / Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers 32 ( ) : 289 ~ 295
Cytogenet Cell Genet 1983;36 / / Catalogue of chromosome aberrations in cancer : 1 ~ 515
Fang G / 1998 / The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation 12 : 187
Feitelson MA / 1999 / Hepatitis B virus in hepatocarcinogenesis 181 : 188 ~ 202
Gemma A / 2001 / Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers 32 ( ) : 289 ~ 295
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