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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 195 - 204 (10page)
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The BubR1 mitotic-checkpoint protein monitors proper attachment of microtubules to kinetochores, and links regulation of chromosome-spindle at-tachment to mitotic-checkpoint signaling. Thus, disruption of BubR1 activity results in a loss of checkpoint control, chromosomal instability caused by a premature anaphase, and/or the early onset of tumorigenesis. The mechanisms by which dere-gulation and/or abnormalities of BubR1 expression operate, however, remain to be elucidated. In this study, we demonstrate that levels of BubR1 ex-pression are significantly increased by demethyla-tion. Bisulfite sequencing analysis revealed that the methylation status of two CpG sites in the essential BubR1 promoter appear to be associated with BubR1 expression levels. Associations of MBD2 and HDAC1 with the BubR1 promoter were significantly relieved by addition of 5-aza-2'-deoxycytidine, an irreversible DNA methyltransferase inhibitor. However, genomic DNA isolated from 31 patients with colorectal carcinomas exhibited a +8 4A/G polymorphic change in approximately 60% of patients, but this poly-morphism had no effect on promoter activity. Our findings indicate that differential regulation of BubR1 expression is associated with changes in BubR1 promoter hypermethylation paterns, but not with promoter polymorphisms, thus providing a novel r regulation of BubR1 expression in human cancer cells.
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참고문헌 (30)
참고문헌 신청
Abrieu A / 2000 / CENP-E as an essential component of the mitotic checkpoint in vitro 102 : 817 ~ 826
Adcock IM / 2006 / Epigenetics and airways disease 7 : 21 ~ 40
Baker DJ / 2004 / BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice 36 : 744 ~ 749
Baylin SB / 2001 / Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer 10 : 687 ~ 692
Bird A / 2002 / DNA methylation patterns and epigenetic memory 16 : 6 ~ 21
Adcock IM / 2006 / Epigenetics and airways disease 7 : 21 ~ 40
Baker DJ / 2004 / BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice 36 : 744 ~ 749
Baylin SB / 2001 / Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer 10 : 687 ~ 692
Bird A / 2002 / DNA methylation patterns and epigenetic memory 16 : 6 ~ 21
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