지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 59 - 70 (12page)
이용수
초록· 키워드
오류제보하기
In many clinical situations which cause thymic in-
volution and thereby result in immune deficiency,T cells are the most often affected,leading to a prolonged
deficiency of T cells.Since only the thymic-dependent
T cell production pathway secures stable regeneration of fully mature T cells,seeking strategies to enhance thymic regeneration should be a key step in developing
therapeutic methods for the treatment of these sig-
nificant clinical problems.This study clearly shows
that receptor activator of NF-κB ligand (RANKL) stim-
ulates mouse thymic epithelial cell activities including
cell proliferation,thymocyte adhesion to thymic epi-thelial cells, and the expression of cell death regulatory
genes favoring cell survival, cell adhesion molecules such as ICAM-1 and VCAM-1, and thymopoietic factors including IL-7. Importantly, RANKL exhibited a sig-
nificant capability to facilitate thymic regeneration in
mice.In addition,this study demonstrates that RANKL
acts directly on the thymus to activate thymus re-
generation regardless of its potential influences on
thymic regeneration through an indirect or systemic
effect.In light of this,the present study provides a
greater insight into the development of novel ther-
apeutic strategies for effective thymus repopulation
using RANKL in the design of therapies for many clin-
ical conditions in which immune reconstitution is
required.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Alpdogan O / 2001 / Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease
Anderson DM / 1997 / A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function / Nature 390 : 175 ~ 179
Aspinall R / 2004 / Interleukin-7: an interleukin for rejuvenating the immune system / Ann NY Acad Sci 1019 : 116 ~ 122
Barda-Saad M / 1996 / Selective adhesion of immature thymocytes to bone marrow stromal cells: relevance to T cell lymphopoiesis / Exp Hematol 24 : 386 ~ 391
Cao Y / 2001 / IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development / Cell 107 : 769 ~ 775
Anderson DM / 1997 / A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function / Nature 390 : 175 ~ 179
Aspinall R / 2004 / Interleukin-7: an interleukin for rejuvenating the immune system / Ann NY Acad Sci 1019 : 116 ~ 122
Barda-Saad M / 1996 / Selective adhesion of immature thymocytes to bone marrow stromal cells: relevance to T cell lymphopoiesis / Exp Hematol 24 : 386 ~ 391
Cao Y / 2001 / IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development / Cell 107 : 769 ~ 775
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Receptor activator of NF-κB ligand enhances the activity of macrophages as antigen presenting cells
Experimental and Molecular Medicine
2005 .01
-
Development of thymic lymphomas in mice disrupted of Brca2allele in the thymus
Experimental and Molecular Medicine
2008 .01
-
Wnt7b is Upregulated in Macrophages during Thymic Regeneration and Negatively Regulated by RANKL
생명과학회지
2007 .07
-
B CELL DIVISIONS IN T CELL DEPENDENT B CELL REACTION
한국미생물학회 학술대회논문집
1997 .04
-
Expression of Stromal Derived Factor-1 is Upregulated in Macrophages during Thymic Regeneration in Adult Rat
생명과학회지
2009 .08
-
Sex-determining region Y (SRY) attributes to gender differences in RANKL expression and incidence of osteoporosis
Experimental and Molecular Medicine
2019 .01
-
TNF-α에 의해 유도된 세포부착분자의 발현에 대한 Delphinidin Chloride의 억제 효과
환경생물
2009 .01
-
The Role of Receptor Activator of NF-кB Ligand in Smooth Muscle Cell Proliferation
생명과학회지
2006 .10
-
Butyrate-induced differentiation of PC12 cells to chromaffin cells involves cell adhesion and induction of extracellular proteins and cell adhesion proteins
Animal cells and systems
2010 .01
-
Understanding of molecular mechanisms in natural killer cell therapy
Experimental and Molecular Medicine
2015 .01
-
Expression of 4-1BB and 4-1BBL in thymocytes during thymus regeneration
Experimental and Molecular Medicine
2009 .01
-
Strategies for Enhanced Regeneration of Hematopoietic Stem Cells
한국동물학회 학술대회
2005 .01
-
Lineage conversion of mouse fibroblasts to pancreatic α-cells
Experimental and Molecular Medicine
2017 .01
-
B cell-associated immune profiles in patients with end-stage renal disease (ESRD)
Experimental and Molecular Medicine
2012 .01
-
In vitro Expansion of Natural Regulatory T Lymphocytes Useful for Cell Therapy in Allotransplantation
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2009 .09
-
혈관내피세포에서 Vascular Cell Adhesion Molecule-1 발현에 대한 혈장 지단백의 효과
한국영양학회지
1998 .10
-
Morphological Image Processing of Bioceramic Foam
Quantitative Bio-Science
2017 .11
-
Mast cells play a key role in Th2 cytokine-dependent asthma model through production of adhesion molecules by liberation of TNF-α
Experimental and Molecular Medicine
2011 .01
-
Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation
Experimental and Molecular Medicine
2017 .01
-
Cellular and Biochemical Alterations in L6 Myoblast Cells Induced by 6-Aminonicotinamide
Integrative biosciences
2007 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0