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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 873 - 879 (7page)
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BubR1 mitotic checkpoint kinase monitors attachment
of microtubules to kinetochores and links regulation
of the chromosome-spindle attachment to mitotic
checkpoint signaling. Defects in BubR1-mediated
signaling severely perturb checkpoint control and
are linked to diseases such as cancer. Studies using
BubR1 mouse models suggest that BubR1 activities
prevent premature aging and infertility. In this study,
we show that BubR1 depletion in human adipose-derived
mesenchymal stem cells (ASCs) precedes loss of
the differentiation potential and induction of replicative
senescence. These effects occur independently
of p16INK4A expression and may involve DNA methylation.
Our results reveal a new and unsuspected feature
of BubR1 expression in regulation of adult stem
cell differentiation.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Baker DJ / 2004 / BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice / Nat Genet 36 : 744 ~ 749
Baker DJ / 2008 / Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency / Nat Cell Biol 10 : 825 ~ 836
Bergelson JM / 1997 / Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5 / Science 275 : 1320 ~ 1323
Cahill DP / 1998 / Mutations of mitotic checkpoint genes in human cancers / Nature 392 : 300 ~ 303
Dai W / 2004 / Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency / Cancer Res 64 : 440 ~ 445
Baker DJ / 2008 / Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency / Nat Cell Biol 10 : 825 ~ 836
Bergelson JM / 1997 / Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5 / Science 275 : 1320 ~ 1323
Cahill DP / 1998 / Mutations of mitotic checkpoint genes in human cancers / Nature 392 : 300 ~ 303
Dai W / 2004 / Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency / Cancer Res 64 : 440 ~ 445
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Differential promoter methylation may be a key molecularmechanism in regulating BubR1 expression in cancer cells
Experimental and Molecular Medicine
2007 .01
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Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas
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2003 .01
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The p90 ribosomal S6 kinase 2 specifically affects mitotic progression by regulating the basal level, distribution and stability of mitotic spindles
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Nuclear receptor regulation of stemness and stem cell differentiation
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DNA methylation: an epigenetic mark of cellular memory
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2017 .01
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Spindle Checkpoint Control in Budding Yeast
The Journal of Microbiology
2001 .03
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The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells
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Differentiation of human gingival mesenchymal stem cells into neuronal lineages in 3D bioconjugated injectable protein hydrogel construct for the management of neuronal disorder
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Mass spectrometry based proteomic analysis of human stemcells: a brief review
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Functional Analysis of the Putative BUB2 Homologues of C. elegans in the Spindle Position Checkpoint
Integrative biosciences
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Regulation of osteogenic differentiation of human adipose-derived stem cells by controlling electromagnetic field conditions
Experimental and Molecular Medicine
2013 .01
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Perspectives of Pancreas Stem Cells: Expansion and Differentiation of Adult Pancreas Stem Cells in vivo and in vitro
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2005 .01
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Directed Differentiation of Pluripotent Stem Cells by Trascription Factors
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