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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 756 - 768 (13page)
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초록· 키워드
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Reactive oxygen species (ROS) play an important role in the pathogenesis of airway inflammation and hyperresponsiveness. Recent studies have demonstrated that antioxidants are able to reduce airway inflammation and hyperreactivity in animal models of allergic airway disease. A newly developed antioxidant, small molecular weight thiol compound, N-acetylcysteine amide (AD4) has been shown to increase cellular levels of glutathione and to attenuate oxidative stress related disorders such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. However, the effects of AD4 on allergic airway disease such as asthma are unknown. We used ovalbumin (OVA)-inhaled mice to evaluate the role of AD4 in allergic airway disease. In this study with OVA-inhaled mice, the increased ROS generation, the increased levels of Th2 cytokines and VEGF, the increased vascular permeability, the increased mucus production, and the increased airway resistance in the lungs were significantly reduced by the administration of AD4. We also found that the administration of AD4 decreased the increases of the NF-κB and hypoxia-inducible factor- 1α (HIF-1α ) levels in nuclear protein extracts of lung tissues after OVA inhalation. These results suggest that AD4 attenuates airway inflammation and hyperresponsiveness by regulating activation of NF-κB and HIF-1α as well as reducing ROS generation in allergic airway disease.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Adam L / 1999 / Nitric oxide modulates beta(2)-adrenergic receptor palmitoylation and signaling 274 : 26337 ~ 26343
Asti C / 1995 / Effectiveness of carbocysteine lysine salt monohydrate on models of airway inflammation and hyperresponsiveness 31 : 387 ~ 392
Atlas D / 1999 / Brain targeted low molecular weight hydrophobic antioxidant compounds (5874468)
Baeuerle PA / 1996 / NF-kapa B: ten years after 87 : 13 ~ 20
Bahat-Stroomza M / 2005 / A novel thiol antioxidant that crosses the blood brain barrier protects dopaminergic neurons in experimental models of Parkinson's disease 21 : 637
Asti C / 1995 / Effectiveness of carbocysteine lysine salt monohydrate on models of airway inflammation and hyperresponsiveness 31 : 387 ~ 392
Atlas D / 1999 / Brain targeted low molecular weight hydrophobic antioxidant compounds (5874468)
Baeuerle PA / 1996 / NF-kapa B: ten years after 87 : 13 ~ 20
Bahat-Stroomza M / 2005 / A novel thiol antioxidant that crosses the blood brain barrier protects dopaminergic neurons in experimental models of Parkinson's disease 21 : 637
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