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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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- 2014.1
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Although some studies have explained the immunomodulatory effects of statins, the exact mechanisms and the therapeutic significance of these molecules remain to be elucidated. This study not only evaluated the therapeutic potential and inhibitory mechanism of simvastatin in an ovalbumin (OVA)-specific asthma model in mice but also sought to clarify the future directions indicated by previous studies through a thorough review of the literature. BALB/c mice were sensitized to OVA and then administered three OVA challenges. On each challenge day, 40mgkg 1 simvastatin was injected before the challenge. The airwayresponsiveness, inflammatory cell composition, and cytokine levels in bronchoalveolar lavage (BAL) fluid were assessed after the final challenge, and the T cell composition and adhesion molecule expression in lung homogenates were determined. The administration of simvastatin decreased the airway responsiveness, the number of airway inflammatory cells, and the interleukin (IL)-4, IL-5 and IL-13 concentrations in BAL fluid compared with vehicle-treated mice (Po0.05). Histologically, the numberof inflammatory cells and mucus-containing goblet cells in lung tissues also decreased in the simvastatin-treated mice. Flow cytometry showed that simvastatin treatment significantly reduced the percentage of pulmonary CD4+ cells and the CD4+/CD8+ T-cell ratio (Po0.05). Simvastatin treatment also decreased the expression of the vascular cell adhesion molecule 1 and intercellular adhesion molecule 1 proteins, as measured in homogenized lung tissues (Po0.05) and human epithelial cells. The reduction in the T cell influx as a result of the decreased expression of cell adhesion molecules is one of the mechanisms by which simvastatin attenuates airway responsiveness and allergic inflammation. Rigorous review of the literature together with our findings suggested that simvastatin should be further developed as a potential therapeutic strategy for allergic asthma.
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참고문헌 (24)
참고문헌 신청
Abdollatif Moini / 2012 / Evaluation of Atorvastatin for the Treatment of Patients With Asthma: A Double-Blind Randomized Clinical Trial / Allergy, Asthma & Immunology R
Ahmad T / 2011 / Simvastatin improves epithelial dysfunction and airway hyperresponsiveness : from asymmetric dimethyl-arginine to asthma / Am J Respir Cell Mol Biol 44 : 53
Barnes PJ / 1998 / Inflammatory mediators of asthma : an update / Pharmacol Rev 50 : 515 ~ 596
Chen YJ / 2010 / Simvastatin attenuates acrolein-induced mucin production in rats : involvement of the Ras/extracellular signal-regulated kinase pathway / Int Immunopharmaco
Chiba Y / 2009 / Lovastatin inhibits antigen-induced airway eosinophilia without affecting the production of inflammatory mediators in mice / Inflamm Res 58 : 363 ~ 369
Ahmad T / 2011 / Simvastatin improves epithelial dysfunction and airway hyperresponsiveness : from asymmetric dimethyl-arginine to asthma / Am J Respir Cell Mol Biol 44 : 53
Barnes PJ / 1998 / Inflammatory mediators of asthma : an update / Pharmacol Rev 50 : 515 ~ 596
Chen YJ / 2010 / Simvastatin attenuates acrolein-induced mucin production in rats : involvement of the Ras/extracellular signal-regulated kinase pathway / Int Immunopharmaco
Chiba Y / 2009 / Lovastatin inhibits antigen-induced airway eosinophilia without affecting the production of inflammatory mediators in mice / Inflamm Res 58 : 363 ~ 369
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