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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 629 - 640 (12page)
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초록· 키워드
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Gap junction channels formed with connexins directly
link to the cytoplasm of adjacent cells and have been
implicated in intercellular signaling. Connexin 37
(Cx37) is expressed in the gas-exchange region of the
lung. Recently, Cx37 has been reported to be involved
in the pathogenesis of inflammatory disease.
However, no data are available on the role of Cx37 in
allergic airway inflammatory disease. In the present
study, we used a murine model of ovalbumin (OVA)- induced
allergic airway disease and primary murine epithelial
cells to examine the change of Cx37 in allergic
airway disease. These mice develop the following typical
pathophysiological features of asthma: airway hyperresponsiveness,
airway inflammation, and increased
IL-4, IL-5, IL-13, intercellular adhesion molecule-
1, vascular cell adhesion molecule-1, eotaxin, and
RANTES levels in lungs. Cx37 protein and mRNA expression
were decreased in OVA-induced allergic airway
disease. Immunoreactive Cx37 localized in epithelial
layers around the bronchioles in control mice,
which dramatically disappeared in allergen-induced
asthmatic lungs. Moreover, the levels of Cx37 protein
in lung tissues showed significantly negative correlations
with airway inflammation, airway responsiveness,
and levels of Th2 cytokines in lungs. These findings
indicate that change of Cx37 may be associated
with the asthma phenotype.
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참고문헌 (26)
참고문헌 신청
/ / Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987 : 156 ~ 9
/ 1996 / Institute of Laboratory Animal Research, Commission of Life Sciences, National Research Council. Guide for the care and use of laboratory animals
Abraham V / 1999 / Phenotypic control Connexin 37 in asthma 639 of gap junctional communication by alveolar epithelial cells 276 : L825 ~ L834
Abraham V / 2001 / Heterocellular gap junctional communication between alveolar epithelial cells 280 : L1085 ~ L1093
Alford AI / 2001 / Extracellular matrix fibronectin alters connexin43 expression by alveolar epithelial cells 280 : L680 ~ L688
/ 1996 / Institute of Laboratory Animal Research, Commission of Life Sciences, National Research Council. Guide for the care and use of laboratory animals
Abraham V / 1999 / Phenotypic control Connexin 37 in asthma 639 of gap junctional communication by alveolar epithelial cells 276 : L825 ~ L834
Abraham V / 2001 / Heterocellular gap junctional communication between alveolar epithelial cells 280 : L1085 ~ L1093
Alford AI / 2001 / Extracellular matrix fibronectin alters connexin43 expression by alveolar epithelial cells 280 : L680 ~ L688
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