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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 1 - 183 (183page)
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Earlier report showed that expression of a splicevariant of CD99 transmembrane protein increasesinvasive ability of human breast cancer cells. Cellmotility was also significantly enhanced by the CD99splice variant expression. In an efort to identify thecellular components that mediate a signal transduc-tion pathway tigered by the CD99 splice variant,known signal path inhibitors were examined for theireffects on the motility of the CD99 splice variant-transfected MDA-MB-231 breast cancer cells. Pheny-larsine oxide, an inhibitor of phosphatase specific forfocal adhesion kinase, and PP1, an inhibitor of srckinase family, significantly suppressed motility of thecells. Among different types of src transfectantclones generated, kinase-negative mutant src trans-fectant cells were 80% less motile than the mockcells transfected with an empty-vector, while v-srcand c-src transfectants exhibited cell motility levelsat or slightly above the mock transfectant. Theseresults suggest that src and focal adhesion kinasemediate the intracellular signaling pathway of a CD99splice variant for the induction of motility of humanbreast cancer cells.
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