지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 193 - 198 (6page)
이용수
초록· 키워드
오류제보하기
GITR (glucocorticoid-induced TNF receptor) is a recently identified member of the TNF receptor superfamily. The receptor is preferentially ex-pressed on CD4+CD25+ regulatory T cells and GITR signals break the supressive activity of the subset. In this study, we wanted to reveal the in vivo function of GITR in herpes simplex virus type 1 (HSV-1) infection. A single injection of anti-GITR mAb (DTA-1) imediately after viral infection significantly increased the number of CD4+and CD8+vation surface marker, and secreting IFN-γ. We confirmed these in vivo observations by showing ex vivo that re-stimulation of CD4+or CD8+T cels with a CD4+ or CD8+ T-cel-specific HSV-1 peptide, respectively, induced a significant eleva-tion in cell proliferation and in IFN-γ secretion. Our results indicate that GITR signals play a critical role in the T-cel imunity to HSV-1.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
/ / A new member of thetumor necrosis factor/nerve growth factor receptor familyinhibits T cell receptor-induced apoptosis (centini g) : 6216 ~ 21
/ / Cytotoxic T lymphocytes specific for herpessimplex virus : 387 ~ 96
/ / Role ofGITR in activation response of T lymphocytes (centini g) : 350 ~ 2
/ 2005 / Stimulation with 4-1BB inhibits chronicgraft-versus-host disease by inducing activation-induced celldeath of donor CD4+ T cells 105 : 2206 ~ 13
/ currbiol1999;9 / Identification of a new member of the tumornecrosis factor family and its receptor : 215 ~ 18
/ / Cytotoxic T lymphocytes specific for herpessimplex virus : 387 ~ 96
/ / Role ofGITR in activation response of T lymphocytes (centini g) : 350 ~ 2
/ 2005 / Stimulation with 4-1BB inhibits chronicgraft-versus-host disease by inducing activation-induced celldeath of donor CD4+ T cells 105 : 2206 ~ 13
/ currbiol1999;9 / Identification of a new member of the tumornecrosis factor family and its receptor : 215 ~ 18
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Prevention of chronic graft-versus-host disease by stimulation with glucocorticoid-induced TNF receptor
Experimental and Molecular Medicine
2006 .01
-
Soluble glucocorticoid-induced TNF receptor (sGITR) induces inflammation in mice
Experimental and Molecular Medicine
2003 .01
-
Induction of nitric oxide synthase (NOS) by soluble glucocorticoid induced tumor necrosis factor receptor (sGITR) is modulated by IFN-γ in murine macrophage
Experimental and Molecular Medicine
2003 .01
-
Constitutive expression of 4-1BB on T cells enhances CD4+ T cell responses
Experimental and Molecular Medicine
2003 .01
-
CD99 type II is a determining factor for the differentiation of primitive neuroectodermal cells
Experimental and Molecular Medicine
2003 .01
-
Intracellular CD154 Expression Reflects Antigen-specific CD8+ T Cells butShows Less Sensitivity than Intracellular Cytokine and MHC TetramerStaining
Journal of Microbiology and Biotechnology
2007 .01
-
사람의 결핵균 특이 CD3+CD4-CD8-γδ T림프구 클론의 항원인지 과정에서 CD1의 역할
The Journal of the Korean Society for Microbiology
1993 .12
-
Proteomic Analysis of Resting and Activated Human CD8+ T Cells
Journal of Microbiology and Biotechnology
2006 .01
-
Detection of homodimer formation of CD99 throughextracelluar domain using bimolecular fluorescencecomplementation analysis
Experimental and Molecular Medicine
2007 .01
-
Characterization of the Herpes Simplex Virus Type 1 (HSV-1) isolated from Korean patients
한국동물학회 학술대회
1999 .01
-
Abscisic acid가 Cd2+에 의한 닭의장풀의 생리적 반응에 미치는 영향
환경생물
2005 .01
-
CD99 activates T cells via a costimulatory function thatpromotes raft association of TCR complex and tyrosinephosphorylation of TCR ζ
Experimental and Molecular Medicine
2007 .01
-
Isolation of CD4 Genomic Clones and Role of Its 5' Upstream Region in CD4 Expression
미생물학회지
1992 .12
-
CD137 induces adhesion and cytokine production in human monocytic THP-1cells
Experimental and Molecular Medicine
2005 .01
-
A decrease in the expression of CD63 tetraspanin protein elevates invasive potential of human melanoma cells
Experimental and Molecular Medicine
2003 .01
-
Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK, JNK and c-Jun pathways in human melanoma cells
Experimental and Molecular Medicine
2005 .01
-
4-1BB Costimulation Enhances HSV-1-Specific CD8⁺ T Cell Responses
한국미생물학회 학술대회논문집
2003 .05
-
Selective addition of CXCR3+CCR4-CD4+ Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro
Experimental and Molecular Medicine
2009 .01
-
Herpes Simplex Virus Type-1 (HSV-1) 감염에 따른 세포내 유리 Ca2+농도의 변화
미생물학회지
2000 .12
-
CD43 cross-linking increases the Fas-induced apoptosis through induction of Fas aggregation in Jurkat T-cells
Experimental and Molecular Medicine
2006 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0