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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 607 - 616 (10page)
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Lysophosphatidic acid (LPA) is a bioactive phospholipids and involves in various cellular events, including tumor cell migration. In the present study, we investigated LPA receptor and its transactivation to EGFR for cyclooxygenase-2 (COX-2) expression and cell migration in CAOV-3 ovarian cancer cells. LPA induced COX-2 expression in a dose-dependent manner, and pretreatment of the cells with pharmacological inhibitors of Gi (pertussis toxin), Src (PP2), EGF receptor (EGFR) (AG1478), ERK (PD98059) significantly inhibited LPA- induced COX-2 expression. Consistent to these results, transfection of the cells with selective Src siRNA attenuated COX-2 expression by LPA. LPA stimulated CAOV-3 cell migration that was abrogated by pharmacological inhibitors and antibody of EP2. Higher expression of LPA2 mRNA was observed in CAOV-3 cells, and transfection of the cells with a selective LPA2 siRNA significantly inhibited LPA-induced activation of EGFR and ERK, as well as COX-2 expression. Importantly, LPA2 siRNA also blocked LPA-induced ovarian cancer cell migration. Collectively, our results clearly show the significance of LPA2 and Gi/Src pathway for LPA-induced COX-2 expression and cell migration that could be a promising drug target for ovarian cancer cell metastasis.
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참고문헌 (22)
참고문헌 신청
An S / 1998 / Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid / J Biol Chem 273 : 7906 ~ 10
Bandoh K / 1999 / Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid / J Biol Chem 274 : 27776 ~ 85
Buchanan FG / 2003 / Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor / J Biol Chem 278 : 35451 ~ 7
Cao Y / 2002 / Many actions of cyclooxygenase-2 in cellular dynamics and in cancer / J Cell Physiol 190 : 279 ~ 86
Contos JJ / 2002 / Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic
Bandoh K / 1999 / Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid / J Biol Chem 274 : 27776 ~ 85
Buchanan FG / 2003 / Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor / J Biol Chem 278 : 35451 ~ 7
Cao Y / 2002 / Many actions of cyclooxygenase-2 in cellular dynamics and in cancer / J Cell Physiol 190 : 279 ~ 86
Contos JJ / 2002 / Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic
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