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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 123 - 134 (12page)
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Lysophosphatidic acid (LPA) is an endogenous lysophospholipid with signaling properties outside of the cell and it signals through specific G protein-coupled receptors, known as LPA1–6. For one of its receptors, LPA1 (gene name Lpar1), details on the cis-acting elements for transcriptional control have not been defined. Using 5′RACE analysis, we report the identification of an alternative transcription start site of mouse Lpar1 and characterize approximately 3,500 bp of non-coding flanking sequence 5′ of mouse Lpar1 gene for promoter activity. Transient transfection of cells derived from mouse neocortical neuroblasts with constructs from the 5′ regions of mouse Lpar1 gene revealed the region between −248 to +225 serving as the basal promoter for Lpar1. This region also lacks a TATA box. For the region between −761 to −248, a negative regulatory element affected the basal expression of Lpar1. This region has three E-box sequences and mutagenesis of these E-boxes, followed by transient expression, demonstrated that two of the E-boxes act as negative modulators of Lpar1. One of these E-box sequences bound the HeLa E-box binding protein (HEB), and modulation of HEB levels in the transfected cells regulated the transcription of the reporter gene. Based on our data, we propose that HEB may be required for a proper regulation of Lpar1 expression in the embryonic neocortical neuroblast cells and to affect its function in both normal brain development and disease settings.
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참고문헌 (58)
참고문헌 신청
Anliker, B. / 2013 / Lysophosphatidic acid(LPA)and its receptor, LPA1, influence embryonic schwann cell migration, myelination, and cell-to-axon segregation / Glia 61:2009~2022
Aoki, J. / 2004 / Mechanisms of lysophosphatidic acid production / Semin. Cell Dev. Biol 15:477~489
Benson, L. Q. / 1999 / Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2 / J. Biol. Chem 274:28794~28802
Birgbauer, E. / 2006 / New developments in the biological functions of lysophospholipids / Cell Mol. Life Sci 63:2695~2701
Burke, T. W. / 1997 / The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila / Genes Dev 11:3020~3031
Aoki, J. / 2004 / Mechanisms of lysophosphatidic acid production / Semin. Cell Dev. Biol 15:477~489
Benson, L. Q. / 1999 / Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2 / J. Biol. Chem 274:28794~28802
Birgbauer, E. / 2006 / New developments in the biological functions of lysophospholipids / Cell Mol. Life Sci 63:2695~2701
Burke, T. W. / 1997 / The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila / Genes Dev 11:3020~3031
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