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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 445 - 452 (8page)
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초록· 키워드
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Akt plays pivotal roles in many physiological responses including growth, proliferation, survival, metabolism, and migration. In the current studies, we have evaluated the isoform-specific role of akt in lysophosphatidic acid (LPA)-induced cell migration. Ascites from ovarian cancer patients (AOCP) induced mouse embryo fibroblast (MEF) cell migration in a dose-dependent manner. On the other hand, ascites from liver cirrhosis patients (ALCP) did not induce MEF cell migration. AOCP-induced MEF cell migration was completely blocked by pre-treatment of cells with LPA receptor antagonist, Ki16425. Both LPA- and AOCP-induced MEF cell migration was completely attenuated by PI3K inhibitor, LY294002. Furthermore, cells lacking Akt1 displayed defect in LPA-induced cell migration. Re-expression of Akt1 in DKO (Akt1-/-Akt2-/-) cells restored LPA-induced cell migration, whereas re-expression of Akt2 in DKO cells could not restore the LPA-induced cell migration. Finally, Akt1 was selectively phosphorylated by LPA and AOCP stimulation.
These results suggest that LPA is a major factor responsible for AOCP-induced cell migration and signaling specificity of Akt1 may dictate LPA-induced cell migration.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Ackah E / 2005 / Akt1/protein kinase Bα is critical for ischemic and VEGF-mediated angiogenesis / J Clin Invest 115 : 2119 ~ 2127
Bae SS / 2003 / Isoform-specific regulation of insulin-dependent glucose uptake by Akt/ protein kinase B / J Biol Chem 278 : 49530 ~ 49536
Baudry A / 2006 / PKBα is required for adipose differentiation of mouse embryonic fibroblasts / J Cell Sci 119 : 889 ~ 897
Bian D / 2004 / Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway / Cancer Res 64 : 4209 ~ 4217
Cho H / 2001 / Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice / J Biol Chem 276 : 38349 ~ 38352
Bae SS / 2003 / Isoform-specific regulation of insulin-dependent glucose uptake by Akt/ protein kinase B / J Biol Chem 278 : 49530 ~ 49536
Baudry A / 2006 / PKBα is required for adipose differentiation of mouse embryonic fibroblasts / J Cell Sci 119 : 889 ~ 897
Bian D / 2004 / Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway / Cancer Res 64 : 4209 ~ 4217
Cho H / 2001 / Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice / J Biol Chem 276 : 38349 ~ 38352
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Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells
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Reactive Oxygen Species Mediates Lysophosphatidic Acid-induced Migration of SKOV-3 Ovarian Cancer Cells
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