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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 328 - 337 (10page)
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초록· 키워드
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We examined whether wogonin (WO) improved hippocampal neuronal activity, behavioral alterations and cognitive impairment, in rats induced by administration of trimethyltin (TMT), an organotin compound that is neurotoxic to these animals. The ability of WO to improve cognitive efficacy in the TMT-induced neurodegenerative rats was investigated using a passive avoidance test, and the Morris water maze test, and using immunohistochemistry to detect components of the acetylcholinergic system, brain-derived neurotrophic factor (BDNF), and cAMP-response element-binding protein (CREB) expression. Rats injected with TMT showed impairments in learning and memory and daily administration of WO improved memory function, and reduced aggressive behavior. Administration of WO significantly alleviated the TMT-induced loss of cholinergic immunoreactivity and restored the hippocampal expression levels of BDNF and CREB proteins and their encoding mRNAs to normal levels. These findings suggest that WO might be useful as a new therapy for treatment of various neurodegenerative diseases.
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참고문헌 (26)
참고문헌 신청
Brabeck, C / 2002 / Expression of EMAP-II by activated monocytes/microglial cells in different regions of the rat hippocampus after trimethyltin-induced brain damage / Exp. Neurol 177:341~346
Chen, S / 2015 / Wogonin inhibits LPS-induced inflammatory responses in rat dorsal root ganglion neurons via inhibiting TLR4-MyD88-TAK1-mediated NF-κB and MAPK signaling pathway / Cell. Mol. Neurobiol 35:523~531
Cho, J / 2004 / Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells / Eur. J. Pharmacol 485:105~110
Frautschy, S. A / 2001 / Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology / Neurobiol. Aging 22:993~1005
Gasparova, Z / 2012 / Early and late stage of neurodegeneration induced by trimethyltin in hippocampus and cortex of male Wistar rats. Neuroendocrinol / Lett 33:689~696
Chen, S / 2015 / Wogonin inhibits LPS-induced inflammatory responses in rat dorsal root ganglion neurons via inhibiting TLR4-MyD88-TAK1-mediated NF-κB and MAPK signaling pathway / Cell. Mol. Neurobiol 35:523~531
Cho, J / 2004 / Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells / Eur. J. Pharmacol 485:105~110
Frautschy, S. A / 2001 / Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology / Neurobiol. Aging 22:993~1005
Gasparova, Z / 2012 / Early and late stage of neurodegeneration induced by trimethyltin in hippocampus and cortex of male Wistar rats. Neuroendocrinol / Lett 33:689~696
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