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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 531 - 540 (10page)
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초록· 키워드
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ObjectiveaaBrain-derived neurotrophic factor (BDNF) and its specific receptor, tropomyosin-related kinase (TrkB), play important roles in treating depression. In this experiment, we examined whether 7,8-dihydroxyflavone, a novel potent TrkB agonist, could reverse the behavioral and biochemical abnormalities induced by the chronic mild stress (CMS) paradigm in rats.
MethodsaaSD rats were exposed to a battery of stressors for 56 days. 7,8-dihydroxyflavone (5 and 20 mg/kg) were administered intraperitoneally during the last 28 days of the CMS paradigm. Rats were tested in sucrose consumption test (SCT), forced-swimming test (FST) and elevated T-maze (ETM). Serum corticosterone levels and hippocampal BDNF levels of the rats were measured.
ResultsaaFour-week CMS on the rats induced their depression-like behavior in SCT. The CMS-reduced sucrose consumption was reversed starting from 7 days after the 7,8-dihydroxyflavone (20 mg/kg) treatment and remained across the subsequent treatment regime.
7,8-dihydroxyflavone, when given at 5 mg/kg for 3 weeks, reduced the immobility time in the FST in the CMS-subjected rats. Additionally, the 4-week treatment with 7,8-dihydroxyflavone (20 mg/kg) attenuated the CMS-induced increase in anxiety-like behavior in the ETM. For the CMS-subjected rats, 7,8-dihydroxyflavone treatment dose-dependently reduced their serum corticosterone levels but increased their hippocampal BDNF levels only at 5 mg/kg.
Conclusion 7,8-dihydroxyflavone was beneficial for both depression and anxiety-like behaviors, and may exert fast-onset antidepressant effects. This provides a new insight into the pharmacological management of depression.
목차
등록된 정보가 없습니다.
참고문헌 (62)
참고문헌 신청
Johnson JE / 1986 / Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells / J Neurosci 6:3031~3038
Castren E / 2013 / Neuronal network plasticity and recovery from depression / JAMA Psychiatry 70:983~989
Molendijk ML / 2011 / Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment / Mol Psychiatry 16:1088~1095
Taliaz D / 2010 / Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis / Mol Psychiatry 15:80~92
Angelucci F / 2005 / BDNF in schizophrenia, depression and corresponding animal models / Mol Psychiatry 10:345~352
Castren E / 2013 / Neuronal network plasticity and recovery from depression / JAMA Psychiatry 70:983~989
Molendijk ML / 2011 / Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment / Mol Psychiatry 16:1088~1095
Taliaz D / 2010 / Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis / Mol Psychiatry 15:80~92
Angelucci F / 2005 / BDNF in schizophrenia, depression and corresponding animal models / Mol Psychiatry 10:345~352
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