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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제1권 제1호
- 발행연도
- 2008.1
- 수록면
- 24 - 28 (5page)
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초록· 키워드
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Objectives. It has been proposed that microbial persistence, superantigen (SA) production, and host T-cell response may
be involved in the development of chronic rhinosinusitis. According to the SA hypothesis, a single intranasal application
of SA such as staphylococcal enterotoxin B (SEB) may induce chronic eosinophilic rhinosinusitis. This study
aimed to develop a rat model of rhinosinusitis induced by intranasally applied SEB.
Methods. Forty L of SEB (100 g/mL) or phosphate buffered saline was applied intranasally through each naris in 4 weekold
Sprague-Dawley test rats (N=36) and controls (N=16), respectively. Following sacrifice at 1, 5, 14, and 28 days,
the obtained nasal cavity and sinuses were prepared for histologic investigation. The histologic sections were examined
in a blind manner for the ratio of the sinus spaces occupied by inflammatory cell clusters and the number of
inflammatory cells in the lamina propria.
Results. Infiltration of neutrophils in the lamina propria and appearance of neutrophil clusters in the sinus spaces were
observed in the SEB-applied rats. The ratio of the sinus spaces occupied by neutrophil clusters and the number of
neutrophils infiltrated in the lamina propria increased significantly at day 1 as compared with the control rats.
Conclusion. Intranasally applied SEB induces acute neutrophilic rhinosinusitis in rats. Eosinophilic inflammation was not
demonstrated. The mere presence of SA in the nose does not necessarily induce SA-induced inflammation, as suggested
by the SA hypothesis.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Bachert C / 2001 / Total and specific IgE in nasal polyps is related to local eosinophilic inflammation / J Allergy Clin Immunol 107 (4) : 607 ~ 614
Bomer K / 1998 / A mouse model of acute bacterial rhinosinusitis / Arch Otolaryngol Head Neck Surg 124 (11) : 1227 ~ 1232
Fujiki M / 1999 / Role of T cells in bronchoalveolar space in the development of interstitial pneumonia induced by superantigen in autoimmune-prone mice / Am J Respir Cell Mo
Jacob A / 2001 / Chronic bacterial rhinosinusitis: description of a mouse model / Arch Otolaryngol Head Neck Surg 127 (6) : 657 ~ 664
Jeon SY / 2005 / Rat model of plateletactivating factor-induced rhinosinusitis / Ann Otol Rhinol Laryngol 114 (5) : 393 ~ 398
Bomer K / 1998 / A mouse model of acute bacterial rhinosinusitis / Arch Otolaryngol Head Neck Surg 124 (11) : 1227 ~ 1232
Fujiki M / 1999 / Role of T cells in bronchoalveolar space in the development of interstitial pneumonia induced by superantigen in autoimmune-prone mice / Am J Respir Cell Mo
Jacob A / 2001 / Chronic bacterial rhinosinusitis: description of a mouse model / Arch Otolaryngol Head Neck Surg 127 (6) : 657 ~ 664
Jeon SY / 2005 / Rat model of plateletactivating factor-induced rhinosinusitis / Ann Otol Rhinol Laryngol 114 (5) : 393 ~ 398
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